phospholemman Activators
The chemical class of Phospholemman Activators comprises various compounds that indirectly influence the activity of Phospholemman. These chemicals operate by modulating second messengers like cAMP and cGMP or influencing enzymes such as protein kinases and phosphodiesterases. The central theme in their action is the modulation of Phospholemman's phosphorylation state, which is a key regulatory mechanism affecting its interaction with the Na+/K+-ATPase pump, crucial for maintaining ion homeostasis in cells.
These activators, through their interaction with receptors or target enzymes, initiate a cascade of intracellular events leading to the activation of protein kinases, which in turn, phosphorylate Phospholemman. The phosphorylated form of Phospholemman exhibits altered interaction with Na+/K+-ATPase, modulating its activity. This modulation plays a significant role in various physiological contexts, such as cardiac cells, where it regulates cardiac output by influencing ion exchange and cellular excitability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. This elevation in cAMP activates PKA, which may phosphorylate Phospholemman, enhancing its activity in modulating the Na+/K+-ATPase pump. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain, a cardiac glycoside, inhibits Na+/K+-ATPase. This inhibition may lead to compensatory activation of Phospholemman to modulate the pump under inhibited conditions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates adenylate cyclase, increasing cAMP production. The increased cAMP activates PKA, potentially influencing Phospholemman phosphorylation and its regulation of Na+/K+-ATPase. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, raising cAMP levels. This activates PKA, which could influence Phospholemman phosphorylation, modulating Na+/K+-ATPase activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates its receptors, increasing cAMP production. The increase in cAMP and subsequent PKA activation could phosphorylate Phospholemman, influencing Na+/K+-ATPase regulation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to beta-adrenergic receptors, increasing cAMP levels. The activation of PKA following this could phosphorylate Phospholemman, affecting its interaction with Na+/K+-ATPase. | ||||||
(±)-Norepinephrine (+)-bitartrate salt | 3414-63-9 | sc-255396 | 1 g | $114.00 | ||
Norepinephrine increases cAMP through beta-adrenergic receptor activation. This triggers PKA activation, potentially leading to Phospholemman phosphorylation and modulated Na+/K+-ATPase activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol esters activate PKC, which can phosphorylate proteins in pathways associated with Phospholemman, potentially modulating its activity in regulating Na+/K+-ATPase. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine activates its receptors leading to increased cAMP and activation of PKA. This could influence Phospholemman phosphorylation and its interaction with Na+/K+-ATPase. | ||||||