p-Waf1/Cip1/CDKN1A p21 Antibody (C-8): sc-377514
- p-Waf1/Cip1/CDKN1A p21 Antibody (C-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- recommended for detection of Ser 146 phosphorylated p21 Waf1/Cip1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for p-Waf1/Cip1/CDKN1A p21 Antibody (C-8) for WB applications. These reagents are now offered in bundles with p-Waf1/Cip1/CDKN1A p21 Antibody (C-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
p-p21 Waf1/Cip1 Antibody (C-8) is a mouse monoclonal IgG1 antibody that detects phosphorylated Ser 146 of p21 Waf1/Cip1 of human origin, in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p21 Waf1/Cip1 plays a crucial role in cell cycle regulation by acting as a potent inhibitor of cyclin-dependent kinases (Cdks), which are essential for cell cycle progression. By binding tightly to Cdks, p21 Waf1/Cip1 prevents the phosphorylation of key substrates like retinoblastoma protein (Rb), thereby halting the transition from G1 phase to S phase of the cell cycle. This regulatory function is particularly important in cellular responses to stress and DNA damage, as p21 Waf1/Cip1 expression is induced by wildtype p53, a critical tumor suppressor. p21 Waf1/Cip1′s ability to modulate Cdk activity underscores its significance in maintaining cellular homeostasis and preventing uncontrolled cell proliferation, making p21 Waf1/Cip1 a vital target for research in cancer biology and therapeutic interventions. Anti-p21 Waf1/Cip1 antibody (C-8) provides a reliable tool for studying the phosphorylation-dependent regulation of p21 Waf1/Cip1 and its role in critical cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Waf1/Cip1/CDKN1A p21 Antibody (C-8) | sc-377514 | 200 µg/ml | $316.00 | |||
p-Waf1/Cip1/CDKN1A p21 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-540732 | 200 µg Ab; 10 µg BP | $354.00 | |||
p-Waf1/Cip1/CDKN1A p21 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-542332 | 200 µg Ab; 20 µg BP | $354.00 | |||
p-Waf1/Cip1/CDKN1A p21 (C-8) Neutralizing Peptide | sc-377514 P | 100 µg/0.5 ml | $68.00 |