p-p120 Antibody (pT910.27): sc-293008

p-p120 Antibody (pT910.27) is a mouse monoclonal IgG1 antibody that detects p120 in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, plays a significant role in cellular adhesion and signaling pathways. p120 is primarily localized in the cytoplasm, nucleus, and cell membrane of vascular endothelial cells, where p120 interacts with E-cadherin and other catenins to form complexes essential for maintaining cell-cell adhesion. p120′s location in the cell facilitates the regulation of cadherin stability and function, which is vital for tissue integrity and cellular communication. p120 is involved in ligand-induced receptor signaling through various growth factor receptors, including EGF, PDGF, and CSF-1, highlighting p120′s role in cellular responses to external stimuli. p120 consists of 968 amino acids and features ten ARM repeats, which are crucial for interactions with other proteins. p120 undergoes post-translational modifications, including phosphorylation, which can influence activity and interactions, thereby impacting cellular processes such as proliferation and migration. With diverse functions and a critical role in cell adhesion and signaling, anti-p120 antibody (pT910.27) serves as an invaluable tool for researchers studying the dynamics of cellular interactions and the underlying mechanisms of various diseases.

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.