p120 Antibody (15D2): sc-23872
- p120 Antibody (15D2) is a mouse monoclonal IgG1 κ, cited in 15 publications, provided at 200 µg/ml
- raised against amino acids 790-911 of p120 of mouse origin
- Anti-p120 Antibody (15D2) is recommended for detection of p120 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- Anti-p120 Antibody (15D2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p120 Antibody (15D2) for WB and IHC(P) applications. These reagents are now offered in bundles with p120 Antibody (15D2) (see ordering information below).
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p120 Antibody (15D2) is a mouse monoclonal IgG1 kappa light chain antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p120 (15D2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p120 plays a crucial role in cellular adhesion by interacting with catenin/cadherin complexes, which are essential for maintaining epithelial tissue integrity. p120 binds to the cytoplasmic tail of E-cadherin, stabilizing its interaction with β-catenin and enhancing E-cadherin′s adhesive properties. This interaction regulates cell-cell adhesion, critical in tissue morphogenesis and maintenance of tissue architecture. p120 also participates in various signaling pathways related to cell proliferation and migration, making p120 significant in normal physiology and disease states, such as cancer, where adhesion dysregulation can lead to metastasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p120 Antibody (15D2) References:
- p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. | Reynolds, AB., et al. 1992. Oncogene. 7: 2439-45. PMID: 1334250
- Phosphorylation and isoform use in p120-catenin during development and tumorigenesis. | Hong, JY., et al. 2016. Biochim Biophys Acta. 1863: 102-14. PMID: 26477567
- p120-catenin in canonical Wnt signaling. | Duñach, M., et al. 2017. Crit Rev Biochem Mol Biol. 52: 327-339. PMID: 28276699
- p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP. | Ouyang, H., et al. 2023. Cell Rep. 42: 113486. PMID: 37995182
- Functions of p120-catenin in physiology and diseases. | Jin, X., et al. 2024. Front Mol Biosci. 11: 1486576. PMID: 39498333
- Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines. | Pierceall, WE., et al. 1995. Oncogene. 11: 1319-26. PMID: 7478552
- Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. | Breen, E., et al. 1995. Ann Surg Oncol. 2: 378-85. PMID: 7496831
- The E-cadherin complex contains the src substrate p120. | Aghib, DF. and McCrea, PD. 1995. Exp Cell Res. 218: 359-69. PMID: 7537697
- Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. | Sacco, PA., et al. 1995. J Biol Chem. 270: 20201-6. PMID: 7650039
- Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. | Knudsen, KA., et al. 1995. J Cell Biol. 130: 67-77. PMID: 7790378
- Beta-catenin expression in human cancers. | Takayama, T., et al. 1996. Am J Pathol. 148: 39-46. PMID: 8546224
- Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat. | Ozawa, M., et al. 1995. J Biochem. 118: 836-40. PMID: 8576101
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p120 Antibody (15D2) | sc-23872 | 200 µg/ml | $316.00 | |||
p120 Antibody (15D2): m-IgG Fc BP-HRP Bundle | sc-528376 | 200 µg Ab; 10 µg BP | $354.00 | |||
p120 Antibody (15D2): m-IgGκ BP-HRP Bundle | sc-520738 | 200 µg Ab, 40 µg BP | $354.00 | |||
p120 Antibody (15D2): m-IgG1 BP-HRP Bundle | sc-542903 | 200 µg Ab; 20 µg BP | $354.00 | |||
p120 Antibody (15D2) AC | sc-23872 AC | 500 µg/ml, 25% agarose | $416.00 | |||
p120 Antibody (15D2) HRP | sc-23872 HRP | 200 µg/ml | $316.00 | |||
p120 Antibody (15D2) FITC | sc-23872 FITC | 200 µg/ml | $330.00 | |||
p120 Antibody (15D2) PE | sc-23872 PE | 200 µg/ml | $343.00 | |||
p120 Antibody (15D2) Alexa Fluor® 488 | sc-23872 AF488 | 200 µg/ml | $357.00 | |||
p120 Antibody (15D2) Alexa Fluor® 546 | sc-23872 AF546 | 200 µg/ml | $357.00 | |||
p120 Antibody (15D2) Alexa Fluor® 594 | sc-23872 AF594 | 200 µg/ml | $357.00 | |||
p120 Antibody (15D2) Alexa Fluor® 647 | sc-23872 AF647 | 200 µg/ml | $357.00 | |||
p120 Antibody (15D2) Alexa Fluor® 680 | sc-23872 AF680 | 200 µg/ml | $357.00 | |||
p120 Antibody (15D2) Alexa Fluor® 790 | sc-23872 AF790 | 200 µg/ml | $357.00 |