p-NF kappa B p105 Antibody (4.Ser 932): sc-293141

p-NFκB p105 Antibody (4.Ser 932) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ser 932 phosphorylated NFκB p105 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-p-NFκB p105 antibody (4.Ser 932) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. NFκB p105 plays a crucial role in regulating immune response and cell survival, functioning as a precursor to active NFκB dimers essential for transcribing genes involved in inflammation, cell proliferation, and apoptosis. Phosphorylation of p105 at Ser 932 significantly influences p105 processing into p50, thereby modulating NFκB activity in response to cellular signals. This post-translational modification is vital for timely NFκB activation, necessary for appropriate cellular response to stress and inflammatory stimuli. Understanding p-NFκB p105 and its phosphorylation status can provide insights into various pathological conditions, including cancer and autoimmune diseases, making p-NFκB p105 monoclonal antibody (4.Ser 932) an invaluable tool for researchers studying NFκB signaling pathways.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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p-NF kappa B p105 Antibody (4.Ser 932) References:

1. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.  |  Tomczak, MF., et al. 2006. J Immunol. 177: 7332-9. PMID: 17082652
2. Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway.  |  Fan, CM. and Maniatis, T. 1991. Nature. 354: 395-8. PMID: 1956402
3. NF-kappaB in the nervous system.  |  Kaltschmidt, B. and Kaltschmidt, C. 2009. Cold Spring Harb Perspect Biol. 1: a001271. PMID: 20066105
4. NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function.  |  Sun, F., et al. 2016. Oncogene. 35: 2299-310. PMID: 26300007
5. Nuclear factor-kappa B subunits and their prognostic cancer-specific survival value in renal cell carcinoma patients.  |  Ng, KL., et al. 2018. Pathology. 50: 511-518. PMID: 29935727
6. Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells.  |  Somma, D., et al. 2021. Front Immunol. 12: 669906. PMID: 34721373
7. A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.  |  Goldhirsh, G., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34873064
8. Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50.  |  Fliegauf, M., et al. 2022. Front Immunol. 13: 965326. PMID: 36105815
9. The multifunctional role of intrinsic disorder in NF-κB signaling.  |  Komives, EA. 2023. Biochem Soc Trans. 51: 2085-2092. PMID: 38095058
10. Lipoarabinomannans derived from different strains of Mycobacterium tuberculosis differentially stimulate the activation of NF-kappa B and KBF1 in murine macrophages.  |  Brown, MC. and Taffet, SM. 1995. Infect Immun. 63: 1960-8. PMID: 7729908

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-NFκB p105 Antibody (4.Ser 932) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-p-NFκB p105 Antibody (4.Ser 932) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-NFκB p105 Antibody (4.Ser 932) Specifications

Alternate Product Name: NFKB1

Product Clone Name: 4.Ser 932

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: Ser 932

Epitope Target: NFκB p105

Epitope Species: human

Product Reactivity/Detection: Ser 932 phosphorylated NFκB p105

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for p-NFκB p105 Antibody (4.Ser 932): AC: Agarose, HRP: Horseradish Peroxidase

The preferred NFκB p50 antibody is NFκB p50 Antibody (E-10): sc-8414.