p-mTOR Antibody (59.Ser 2448): sc-293133

p-mTOR Antibody (59.Ser 2448) is a mouse monoclonal IgG1 kappa light chain antibody that detects phosphorylated mTOR at Ser 2448 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-mTOR (59.Ser 2448) antibody is available in both conjugated and non-conjugated forms, providing versatility for various experimental needs. The mechanistic target of rapamycin (mTOR) plays a crucial role in cellular growth and metabolism, acting as a central regulator of cell proliferation and survival by integrating signals from nutrients, growth factors, and cellular energy status. This regulation is vital for maintaining cellular homeostasis and responding to environmental changes, making mTOR a key player in processes such as autophagy, protein synthesis, and cell cycle progression. Dysregulation of mTOR signaling has been implicated in numerous diseases, including cancer, metabolic disorders, and neurodegenerative conditions, highlighting the importance of studying phosphorylation states. The phosphorylation of mTOR at Ser2448, specifically, is mediated by p70S6 kinase and is essential for activation, further underscoring the significance of anti-mTOR antibody (59.Ser 2448) in research focused on mTOR-related pathways and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p-mTOR Antibody (59.Ser 2448) References:

1. Data display records for patients with cardiac pacing.  |  Levander-Lindgren, M. 1976. Acta Med Scand Suppl. 596: 77-9. PMID: 1070231
2. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.  |  Chiang, GG. and Abraham, RT. 2005. J Biol Chem. 280: 25485-90. PMID: 15899889
3. Expression of phosphorylated mTOR and its regulatory protein is related to biological behaviors of ameloblastoma.  |  Li, N., et al. 2012. Int J Clin Exp Pathol. 5: 660-7. PMID: 22977662
4. Roles of mTOR and p-mTOR in gastrointestinal stromal tumors.  |  Li, JC., et al. 2013. Asian Pac J Cancer Prev. 14: 5925-8. PMID: 24289602
5. Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer.  |  Lee, JH., et al. 2015. Int J Clin Exp Pathol. 8: 2987-93. PMID: 26045808
6. When is a lipid kinase not a lipid kinase? When it is a protein kinase.  |  Hunter, T. 1995. Cell. 83: 1-4. PMID: 7553860
7. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.  |  Keith, CT. and Schreiber, SL. 1995. Science. 270: 50-1. PMID: 7569949
8. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.  |  Hartley, KO., et al. 1995. Cell. 82: 849-56. PMID: 7671312
9. Discovery of AT gene sparks biomedical research bonanza.  |  Nowak, R. 1995. Science. 268: 1700-1. PMID: 7792589
10. A single ataxia telangiectasia gene with a product similar to PI-3 kinase.  |  Savitsky, K., et al. 1995. Science. 268: 1749-53. PMID: 7792600

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-mTOR Antibody (59.Ser 2448) has 141 citations in a variety of scientific publications.

Primary antibodies like Anti-p-mTOR Antibody (59.Ser 2448) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-mTOR Antibody (59.Ser 2448) Specifications

Alternate Product Name: mTOR

Product Clone Name: 59.Ser 2448

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Ser 2448

Epitope Target: mTOR

Epitope Species: human

Product Reactivity/Detection: Ser 2448 phosphorylated mTOR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 141 citations in various scientific publications

Available Conjugates/Forms for p-mTOR Antibody (59.Ser 2448): AC: Agarose, HRP: Horseradish Peroxidase

The preferred p-mTOR antibody is p-mTOR Antibody (296.Ser 2481): sc-293132.