p-mTOR Antibody (Ser 2481 55.42): sc-293089

p-mTOR Antibody (Ser 2481 55.42) is a mouse monoclonal IgG1 kappa light chain antibody that detects the phosphorylated form of mechanistic target of rapamycin (mTOR) at Ser 2481 in human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-mTOR antibody (55.42) is available in both conjugated and non-conjugated formats, providing flexibility for various experimental needs. mTOR plays a crucial role in cellular growth and metabolism by integrating signals from nutrients, growth factors, and cellular energy status, making mTOR a key regulator in processes such as protein synthesis and autophagy. mTOR is primarily located in the cytoplasm and nucleus, where mTOR forms complexes with other proteins to modulate signaling pathways that influence cell proliferation and survival. Dysregulation of mTOR signaling has been implicated in numerous diseases, including cancer, metabolic disorders, and neurodegenerative diseases, highlighting the importance of studying mTOR phosphorylation status. Phosphorylation of mTOR at Ser 2481 is particularly significant as this modification occurs under conditions of translational repression, indicating a potential mechanism by which cells adapt to stress. Understanding the dynamics of mTOR phosphorylation can provide insights into therapeutic strategies targeting mTOR in various pathologies.

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p-mTOR Antibody (Ser 2481 55.42) References:

1. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin.  |  Monfrecola, G., et al. 2016. Exp Dermatol. 25: 153-5. PMID: 26477999
2. Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia.  |  Park, JA. and Lee, CH. 2017. J Vet Sci. 18: 11-16. PMID: 27297423
3. Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer.  |  Cao, GD., et al. 2016. PLoS One. 11: e0168085. PMID: 28005970
4. Phosphorylated Mechanistic Target of Rapamycin (p-mTOR) and Noncoding RNA Expression in Follicular and Hürthle Cell Thyroid Neoplasm.  |  Covach, A., et al. 2017. Endocr Pathol. 28: 207-212. PMID: 28660408
5. Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.  |  Oka, SI., et al. 2017. J Biol Chem. 292: 18988-19000. PMID: 28939765
6. Mechanistic target of rapamycin: integrating growth factor and nutrient signaling in the collecting duct.  |  Brown, AL., et al. 2018. Am J Physiol Renal Physiol. 315: F413-F416. PMID: 29846113
7. Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway.  |  Laribee, RN. 2018. J Mol Biol. 430: 4874-4890. PMID: 30359581
8. Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†.  |  Gupta, MB. and Jansson, T. 2019. Biol Reprod. 100: 872-884. PMID: 30476008
9. Supply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cells.  |  Hu, L., et al. 2020. Food Funct. 11: 883-894. PMID: 31942894
10. Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours.  |  Mathew, R., et al. 2021. J Comp Pathol. 184: 60-64. PMID: 33894879

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-mTOR Antibody (Ser 2481 55.42) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-p-mTOR Antibody (Ser 2481 55.42) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-mTOR Antibody (Ser 2481 55.42) Specifications

Alternate Product Name: mTOR

Product Clone Name: Ser 2481 55.42

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Ser 2481

Epitope Target: mTOR

Epitope Species: human

Product Reactivity/Detection: Ser 2481 phosphorylated mTOR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for p-mTOR Antibody (Ser 2481 55.42): AC: Agarose, HRP: Horseradish Peroxidase

The preferred p-mTOR antibody is p-mTOR Antibody (59.Ser 2448): sc-293133.