p-EGFR Antibody (8B8): sc-81490
- p-EGFR Antibody (8B8) is a mouse monoclonal IgG2b, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against synthetic phosphopeptide corresponding to amino acid residues surrounding tyrosine 1086 of EGFR of human origin
- recommended for detection of Tyr 1086 phosphorylated EGFR of human origin by WB and IP; non cross-reactive with non-phosphorylated EGFR or unrelated p-Tyr proteins
- See EGFR (A-10): sc-373746 for p-EGFR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-EGFR Antibody (8B8). This work is in progress.
QUICK LINKS
SEE ALSO...
p-EGFR Antibody (8B8) is a mouse monoclonal IgG2b antibody that detects epidermal growth factor receptor (EGFR) in human samples through western blotting (WB) and immunoprecipitation (IP). anti-EGFR antibody (8B8) is raised against synthetic phosphopeptide corresponding to amino acid residues surrounding tyrosine 1086 of EGFR of human origin to specifically recognize phosphorylated forms of EGFR, which is crucial for understanding cell signaling and growth regulation. EGFR is primarily located on the cell surface, where EGFR functions as a receptor for epidermal growth factors, mediating cellular processes including proliferation, differentiation, and survival. EGFR′s location enables rapid detection and response to extracellular cues, ensuring precise activation of downstream signaling cascades. Surface positioning allows coordinated interactions with signaling molecules and membrane-bound co-receptors, fine-tuning cellular responses. Surface localization is critical for enabling ligand-induced dimerization, a necessary step for activating intrinsic tyrosine kinase activity. Dysregulation of EGFR signaling is implicated in numerous cancers, making EGFR a significant target for therapeutic intervention. Phosphorylation of specific tyrosine residues on EGFR, such as Tyr 1092 and Tyr 1173, is essential for activation and subsequent signaling cascades, highlighting the importance of monitoring these modifications in research and clinical settings. EGFR monoclonal antibody (8B8) helps researchers gain insights into EGFR activation status and downstream effects, contributing to understanding cancer biology and potential treatment strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-EGFR Antibody (8B8) | sc-81490 | 50 µg/0.5 ml | $316.00 |