Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Epidermal growth factors mediate their effects on cell growth through interactions with a cell surface glycoprotein designated EGFR (EGF receptor). Binding of EGF or TGFα to EGFR activates tyrosine-specific protein kinase activity intrinsic to EGFR. The carboxy terminal tyrosine residues on EGFR, Tyr 1092 and Tyr 1173, designated Tyr 1196 in rat, are the major sites of autophosphorylation which occurs as a result of EGF binding. Once activated, EGFR mediates the binding of the phosphotyrosine binding (PTB) domain of GRB2 through direct interactions with Tyr 1092 and Tyr 1110 in human and mouse or Tyr 1109 in rat, and through indirect interactions with Tyr 1173 in the Ras signaling pathway. Tyr 1173 of EGFR also functions as a kinase substrate. Phosphorylation of Tyr 992, Tyr 1092 and Tyr 1110 is required for conformational change in the C-terminal tail of EGFR. Tyr 1092, Tyr 1173 and Tyr 1110 are also designated Tyr 1068, Tyr 1197, and Tyr 1086, respectively.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.