p-Akt1/2/3 Antibody (11E6): sc-81433

p-Akt1/2/3 Antibody (11E6) is a mouse monoclonal IgG1 kappa light chain antibody that detects p-Akt1/2/3 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP). p-Akt1/2/3 monoclonal antibody (11E6) is available in a non-conjugated form, allowing for versatile applications in research. The Akt family of serine/threonine kinases, which includes Akt1, Akt2, and Akt3, plays a crucial role in various cellular processes, including metabolism, cell survival, and growth. These proteins are primarily located in the cytoplasm and are activated in response to growth factors such as insulin and platelet-derived growth factor (PDGF). The activation of Akt1 and Akt2 is linked to the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is essential for mediating cellular responses to insulin and other growth factors. Notably, Akt3, while also activated by insulin, has a unique regulatory mechanism that involves protein kinase C, highlighting the complexity of activation and function. The phosphorylation of these Akt proteins at specific serine and threonine residues is critical for activation and subsequent signaling, influencing processes such as glucose uptake, apoptosis, and cellular proliferation. Understanding the dynamics of Akt activation and downstream effects is vital for elucidating roles in metabolic diseases and cancer, making anti-p-Akt1/2/3 antibody (11E6) an invaluable tool for researchers studying these pathways.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Akt1/2/3 Antibody (11E6) has 82 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Akt1/2/3 Antibody (11E6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Akt1/2/3 Antibody (11E6) Specifications

Alternate Product Name: Akt1/2/3

Product Clone Name: 11E6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Ser 473

Epitope Target: Akt1

Epitope Species: human

Product Reactivity/Detection: Ser 473 phosphorylated Akt1 and correspondingly Ser 474 phosphorylated Akt2 and correspondingly Ser 472 phosporylated Akt3

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 82 citations in various scientific publications

Available Conjugates/Forms for p-Akt1/2/3 Antibody (11E6): N/A

The preferred Akt1 antibody is Akt1 Antibody (B-1): sc-5298.