OTK18 Antibody (E-9): sc-393751

OTK18 Antibody (E-9) is a mouse monoclonal IgG2a antibody that detects Zinc Finger Protein 175 (ZNF175) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF175 monoclonal antibody (E-9) recognizes ZNF175, a 711 amino acid protein that belongs to the Krüppel C2H2-type zinc-finger protein family, which plays a crucial role in transcriptional regulation. ZNF175 is primarily localized in both the nucleus and cytosol, where ZNF175 contains 15 C2H2-type zinc fingers and a KRAB domain, the latter of which is believed to interact with KAP1, facilitating the recruitment of histone-modifying proteins that are essential for chromatin remodeling and gene expression regulation. Notably, ZNF175 is induced by HIV-1 infection and functions as a transcriptional suppressor in this context, highlighting ZNF175′s importance in the cellular response to viral infection and potential implications in understanding HIV pathogenesis. ZNF175 (E-9) antibody effectively detects ZNF175, making ZNF175 monoclonal antibody (E-9) a valuable tool for researchers studying the intricate mechanisms of transcriptional regulation and the role of zinc-finger proteins in various biological processes.

The preferred OTK18 antibody is OTK18 Antibody (211-3.1-1): sc-135814.