OTK18 Antibody (211-3.1-1): sc-135814
- OTK18 Antibody (211-3.1-1) is a mouse monoclonal IgG1 κ OTK18 antibody provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-178 of OTK18 of human origin
- OTK18 Antibody (211-3.1-1) is recommended for detection of amino acids 1-178 of OTK18 of human origin by WB, IP, IF and ELISA
- Anti-OTK18 Antibody (211-3.1-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OTK18 Antibody (211-3.1-1) for WB applications. These reagents are now offered in bundles with OTK18 Antibody (211-3.1-1) (see ordering information below).
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OTK18 Antibody (211-3.1-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects OTK18 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OTK18 (211-3.1-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OTK18, also known as zinc finger protein 175 (ZNF175), is a 711 amino acid member of the Krüppel C2H2-type zinc-finger protein family, characterized by 15 C2H2-type zinc fingers and a single KRAB domain. ZNF175 is primarily localized in the nucleus and cytosol, where ZNF175 plays a crucial role in transcriptional regulation. ZNF175 is induced by HIV-1 infection and functions as a transcriptional suppressor, thereby influencing the expression of genes involved in the viral life cycle and host immune response. ZNF175′s ability to interact with other proteins, such as KAP1, highlights ZNF175′s importance in recruiting histone-modifying proteins, which can lead to changes in chromatin structure and gene expression. Anti-OTK18 antibody (211-3.1-1) serves as an essential tool for researchers studying the molecular mechanisms of HIV-1 and the broader implications of zinc-finger proteins in gene regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OTK18 Antibody (211-3.1-1) References:
- Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. | Walter, L. and Günther, E. 2000. Immunogenetics. 51: 829-37. PMID: 10970097
- Identification of multiple differentially expressed messenger RNAs in normal and pathological trophoblast. | Durand, S., et al. 2003. Placenta. 24: 209-18. PMID: 12566248
- Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. | Carlson, KA., et al. 2004. J Immunol. 172: 381-91. PMID: 14688346
- OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. | Carlson, KA., et al. 2004. J Neuroimmunol. 150: 186-98. PMID: 15081264
- Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors. | Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
- Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins. | Berg, JM. 1988. Proc Natl Acad Sci U S A. 85: 99-102. PMID: 3124104
- Finger proteins and DNA-specific recognition: distinct patterns of conserved amino acids suggest different evolutionary modes. | Payre, F. and Vincent, A. 1988. FEBS Lett. 234: 245-50. PMID: 3292287
- Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. | Abrink, M., et al. 1995. DNA Cell Biol. 14: 125-36. PMID: 7865130
- Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. | Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OTK18 Antibody (211-3.1-1) | sc-135814 | 200 µg/ml | $322.00 | |||
OTK18 Antibody (211-3.1-1): m-IgG Fc BP-HRP Bundle | sc-527102 | 200 µg Ab; 10 µg BP | $361.00 | |||
OTK18 Antibody (211-3.1-1): m-IgG1 BP-HRP Bundle | sc-532475 | 200 µg Ab; 20 µg BP | $361.00 | |||
OTK18 Antibody (211-3.1-1) AC | sc-135814 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OTK18 Antibody (211-3.1-1) HRP | sc-135814 HRP | 200 µg/ml | $322.00 | |||
OTK18 Antibody (211-3.1-1) FITC | sc-135814 FITC | 200 µg/ml | $336.00 | |||
OTK18 Antibody (211-3.1-1) PE | sc-135814 PE | 200 µg/ml | $349.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 488 | sc-135814 AF488 | 200 µg/ml | $364.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 546 | sc-135814 AF546 | 200 µg/ml | $364.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 594 | sc-135814 AF594 | 200 µg/ml | $364.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 647 | sc-135814 AF647 | 200 µg/ml | $364.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 680 | sc-135814 AF680 | 200 µg/ml | $364.00 | |||
OTK18 Antibody (211-3.1-1) Alexa Fluor® 790 | sc-135814 AF790 | 200 µg/ml | $364.00 |