Date published: 2025-10-24

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OPN1SW Antibody (1B10): sc-517304

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Datasheets
  • OPN1SW Antibody (1B10) is a mouse monoclonal IgG2b κ OPN1SW antibody, cited in 1 publications, provided at 200 µg/ml
  • raised against purified OPN1SW of human origin
  • recommended for detection of OPN1SW of human origin by WB
  • m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OPN1SW Antibody (1B10) for WB applications. These reagents are now offered in bundles with OPN1SW Antibody (1B10) (see ordering information below).

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OPN1SW Antibody (1B10) is a mouse monoclonal IgG2b kappa light chain antibody that detects the OPN1SW protein of human origin by western blotting (WB). Anti-OPN1SW antibody (1B10) is available as the non-conjugated format. OPN1SW, also known as blue-sensitive opsin, plays a pivotal role in human color vision by mediating the perception of blue light through its function in the cone cells of the retina. OPN1SW is primarily located in the photoreceptor cells of the retina, where OPN1SW is essential for the phototransduction process, converting light into electrical signals that the brain interprets as visual information. The precise localization of OPN1SW in the cone cells is crucial, as OPN1SW allows for the differentiation of colors, particularly in the blue spectrum, which is vital for normal color perception. The interaction of OPN1SW with the retinaldehyde chromophore enables absorption of light at specific wavelengths, and any disruption in this localization or function can lead to color vision deficiencies. Mutations in the gene encoding OPN1SW have been linked to various forms of color blindness, underscoring OPN1SW′s importance not only in visual acuity but also in the broader context of understanding and potentially treating color vision disorders.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

OPN1SW Antibody (1B10) References:

  1. The DNA sequence of human chromosome 7.  |  Hillier, LW., et al. 2003. Nature. 424: 157-64. PMID: 12853948
  2. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.  |  Weitz, CJ., et al. 1992. Am J Hum Genet. 50: 498-507. PMID: 1531728
  3. The neurobiology of Williams syndrome: cascading influences of visual system impairment?  |  Eckert, MA., et al. 2006. Cell Mol Life Sci. 63: 1867-75. PMID: 16810457
  4. Shwachman-Diamond syndrome.  |  Shimamura, A. 2006. Semin Hematol. 43: 178-88. PMID: 16822460
  5. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
  6. Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.  |  Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
  7. Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies.  |  Brezinová, J., et al. 2007. Cancer Genet Cytogenet. 173: 10-6. PMID: 17284364
  8. Therapy-related leukemia and myelodysplasia: susceptibility and incidence.  |  Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
  9. Tritan color vision deficiency may be associated with an OPN1SW splicing defect and haploinsufficiency.  |  Neitz, M., et al. 2020. J Opt Soc Am A Opt Image Sci Vis. 37: A26-A34. PMID: 32400513
  10. Gene Therapy in Opn1mw-/-/Opn1sw-/- Mice and Implications for Blue Cone Monochromacy Patients with Deletion Mutations.  |  Ma, X., et al. 2022. Hum Gene Ther. 33: 708-718. PMID: 35272502
  11. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.  |  Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
  12. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

OPN1SW Antibody (1B10)

sc-517304
200 µg/ml
$316.00

OPN1SW Antibody (1B10): m-IgGκ BP-HRP Bundle

sc-536521
200 µg Ab; 40 µg BP
$354.00

OPN1SW Antibody (1B10): m-IgG2b BP-HRP Bundle

sc-549548
200 µg Ab; 10 µg BP
$354.00