OGG1/2 Antibody (G-5): sc-376935

OGG1/2 Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects the OGG1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OGG1/2 (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OGG1/2 protein plays a crucial role in DNA repair, specifically targeting 8-oxoguanine, a common form of oxidative DNA damage that can lead to mutagenesis if left unrepaired. OGG1/2 protein is essential for maintaining genomic stability, as the accumulation of 8-oxoguanine can result in A:T to C:G or G:C to T:A transversion mutations due to its ability to form stable base pairs with adenine and cytosine. The OGG1 gene encodes multiple isoforms through alternative splicing, with OGG1A being the most prevalent and localized in the nucleus, while OGG2A is found in the mitochondria. Proper functioning of OGG1/2 is vital, as inactivation of the OGG1 gene can lead to a mutator phenotype, increasing the risk of cancer and other genetic disorders.

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OGG1/2 Antibody (G-5) References:

1. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.  |  Nishioka, K., et al. 1999. Mol Biol Cell. 10: 1637-52. PMID: 10233168
2. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.  |  Minowa, O., et al. 2000. Proc Natl Acad Sci U S A. 97: 4156-61. PMID: 10725358
3. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.  |  Boiteux, S. and Radicella, JP. 2000. Arch Biochem Biophys. 377: 1-8. PMID: 10775435
4. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.  |  Tyrberg, B., et al. 2002. BMC Endocr Disord. 2: 2. PMID: 12003641
5. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.  |  Cheng, KC., et al. 1992. J Biol Chem. 267: 166-72. PMID: 1730583
6. Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.  |  Daimon, M., et al. 2009. Biochem Biophys Res Commun. 386: 26-9. PMID: 19486888
7. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.  |  Shibutani, S., et al. 1991. Nature. 349: 431-4. PMID: 1992344
8. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.  |  Kim, SJ., et al. 2014. J Biol Chem. 289: 6165-76. PMID: 24429287
9. Long non‑coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR‑4728‑5p/OGG1 axis.  |  Zhou, T., et al. 2020. Int J Mol Med. 46: 1838-1848. PMID: 33000245
10. MRC-5 Human Lung Fibroblasts Alleviate the Genotoxic Effect of Fe-N Co-Doped Titanium Dioxide Nanoparticles through an OGG1/2-Dependent Reparatory Mechanism.  |  Miu, BA., et al. 2023. Int J Mol Sci. 24: PMID: 37047374
11. Oxidants, antioxidants, and the degenerative diseases of aging.  |  Ames, BN., et al. 1993. Proc Natl Acad Sci U S A. 90: 7915-22. PMID: 8367443
12. Age-associated damage in mitochondrial DNA in human hearts.  |  Hayakawa, M., et al. 1993. Mol Cell Biochem. 119: 95-103. PMID: 8455592

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OGG1/2 Antibody (G-5) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-OGG1/2 Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OGG1/2 Antibody (G-5) Specifications

Alternate Product Name: OGG1

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 13-49

Epitope Target: OGG1/2

Epitope Species: human

Product Reactivity/Detection: OGG1 and OGG2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for OGG1/2 Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin