OCRL Antibody (C-2): sc-393577

OCRL Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects OCRL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-OCRL antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OCRL protein, a type II inositol polyphosphate 5-phosphatase, plays a crucial role in cellular signaling by selectively dephosphorylating phosphatidylinositol 4,5-bisphosphate and other phosphoinositides, which are vital for generating second messengers in response to extracellular stimuli. Mutations in the OCRL1 gene are associated with the oculocerebrorenal syndrome of Lowe, a rare X-linked disorder characterized by congenital cataracts, cognitive impairment, muscular hypotonia, and renal tubular dysfunction. OCRL1 is localized to the Golgi complex and is involved in the trans-Golgi network, highlighting its importance in protein sorting and trafficking within the cell. OCRL1′s ability to interact with specific phosphoinositides underscores its significance in maintaining cellular homeostasis and signaling pathways, making OCRL (C-2) antibody an essential tool for researchers studying these critical biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

OCRL Antibody (C-2) References:

1. The role of phosphatases in inositol signaling reactions.  |  Majerus, PW., et al. 1999. J Biol Chem. 274: 10669-72. PMID: 10196133
2. Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells.  |  Dressman, MA., et al. 2000. J Histochem Cytochem. 48: 179-90. PMID: 10639484
3. Carrier assessment in families with lowe oculocerebrorenal syndrome: novel mutations in the OCRL1 gene and correlation of direct DNA diagnosis with ocular examination.  |  Röschinger, W., et al. 2000. Mol Genet Metab. 69: 213-22. PMID: 10767176
4. The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.  |  Zhang, X., et al. 1995. Proc Natl Acad Sci U S A. 92: 4853-6. PMID: 7761412
5. Regulation of second messengers by the inositol polyphosphate 5-phosphatases.  |  Mitchell, CA., et al. 1996. Biochem Soc Trans. 24: 994-1000. PMID: 8968499
6. Phosphatidylinositol signalling reactions.  |  Zhang, X. and Majerus, PW. 1998. Semin Cell Dev Biol. 9: 153-60. PMID: 9599410
7. The diversity and possible functions of the inositol polyphosphate 5-phosphatases.  |  Erneux, C., et al. 1998. Biochim Biophys Acta. 1436: 185-99. PMID: 9838104

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OCRL Antibody (C-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-OCRL Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OCRL Antibody (C-2) Specifications

Alternate Product Name: OCRL

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-240

Epitope Target: OCRL

Epitope Species: human

Product Reactivity/Detection: OCRL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for OCRL Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin