OBFC1 Antibody (A-6): sc-374178

OBFC1 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects OBFC1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OBFC1, or oligonucleotide/oligosaccharide-binding fold containing 1, is a 368 amino acid protein that plays a crucial role in nucleic acid binding, which is essential for various cellular processes including DNA replication, repair, and transcription. OBFC1 is primarily located in the nucleus, where OBFC1 interacts with nucleic acids and is involved in maintaining genomic stability. OBFC1′s ability to bind to single-stranded DNA and RNA makes anti-OBFC1 antibody (A-6) vital for the proper functioning of the cellular machinery that ensures accurate genetic information transfer and response to cellular stress. Additionally, OBFC1 may exist in two isoforms due to alternative splicing, which can influence functional properties and interactions with other proteins. OBFC1′s versatility in binding nucleic acids underscores OBFC1′s importance in cellular processes, making OBFC1 (A-6) antibody an invaluable tool for researchers studying nucleic acid dynamics and related pathways in human cells.

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OBFC1 Antibody (A-6) References:

1. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.  |  Wan, M., et al. 2009. J Biol Chem. 284: 26725-31. PMID: 19648609
2. Identification of seven loci affecting mean telomere length and their association with disease.  |  Codd, V., et al. 2013. Nat Genet. 45: 422-7, 427e1-2. PMID: 23535734
3. Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease.  |  Maubaret, CG., et al. 2013. PLoS One. 8: e83122. PMID: 24349443
4. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.  |  Phelan, CM., et al. 2017. Nat Genet. 49: 680-691. PMID: 28346442
5. Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population.  |  Li, C., et al. 2017. Oncotarget. 8: 56932-56941. PMID: 28915643
6. Pulmonary phenotypes associated with genetic variation in telomere-related genes.  |  Hoffman, TW., et al. 2018. Curr Opin Pulm Med. 24: 269-280. PMID: 29474209
7. Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1.  |  Cardinale, A., et al. 2022. Hum Mol Genet. 31: 863-874. PMID: 34605909
8. Transcriptomic Analysis of Conserved Telomere Maintenance Component 1 (CTC1) and Its Association with Leukemia.  |  Zia, S., et al. 2022. J Clin Med. 11: PMID: 36233645
9. Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach.  |  Muiño, E., et al. 2024. Neurology. 103: e209666. PMID: 39298701
10. An Innovative Telomere-associated Prognosis Model in AML: Predicting Immune Infiltration and Treatment Responsiveness.  |  Song, B., et al. 2024. Curr Med Chem.. PMID: 39506437

The preferred OBFC1 antibody is OBFC1 Antibody (E-10): sc-376450.