OATP-C Antibody (A-3): sc-271157

OATP-C Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects OATP-C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-OATP-C antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OATP-C protein, also known as Solute Carrier Organic Anion Transporter Family Member 1B1, plays a crucial role in hepatic uptake of various organic anions, including cardiac glycosides and certain drugs like pravastatin. Exclusive localization to basolateral membrane of hepatocytes facilitates transport of substrates from bloodstream into liver cells, influencing drug metabolism and clearance. OATP-C expression is modulated by compounds such as phenobarbital and pregnenolone-16a-carbonitrile, which can enhance uptake capacity for cardiac glycosides, highlighting importance in pharmacokinetics and potential drug interactions. While OATP-C mRNA levels fluctuate during pregnancy, protein levels remain relatively stable, indicating tightly regulated expression essential for maintaining liver function and homeostasis. OATP-C serves as a vital target for studies related to liver function, drug transport, and pharmacological effects of various compounds in mouse, rat, and human models.

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OATP-C Antibody (A-3) References:

1. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.  |  Hsiang, B., et al. 1999. J Biol Chem. 274: 37161-8. PMID: 10601278
2. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.  |  König, J., et al. 2000. Am J Physiol Gastrointest Liver Physiol. 278: G156-64. PMID: 10644574
3. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.  |  König, J., et al. 2000. J Biol Chem. 275: 23161-8. PMID: 10779507
4. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver.  |  Cattori, V., et al. 2000. FEBS Lett. 474: 242-5. PMID: 10838093
5. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin.  |  Cao, J., et al. 2001. Hepatology. 33: 140-7. PMID: 11124830
6. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney.  |  Isern, J., et al. 2001. Biochim Biophys Acta. 1518: 73-8. PMID: 11267661
7. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.  |  Rausch-Derra, LC., et al. 2001. Hepatology. 33: 1469-78. PMID: 11391536
8. Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.  |  Oswald, M., et al. 2001. Liver. 21: 247-53. PMID: 11454187
9. Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.  |  Tamai, I., et al. 2001. Pharm Res. 18: 1262-9. PMID: 11683238
10. Bile salt transporters.  |  Meier, PJ. and Stieger, B. 2002. Annu Rev Physiol. 64: 635-61. PMID: 11826283
11. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.  |  Nishizato, Y., et al. 2003. Clin Pharmacol Ther. 73: 554-65. PMID: 12811365
12. Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.  |  Mwinyi, J., et al. 2004. Clin Pharmacol Ther. 75: 415-21. PMID: 15116054

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OATP-C Antibody (A-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-OATP-C Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OATP-C Antibody (A-3) Specifications

Alternate Product Name: SLCO1B1

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 606-665

Epitope Target: OATP-C

Epitope Species: human

Product Reactivity/Detection: OATP-C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for OATP-C Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin