OAT3 Antibody (3C11): sc-293264

OAT3 Antibody (3C11) is a mouse monoclonal IgG2b kappa light chain antibody that detects OAT3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-OAT3 antibody (3C11) is available as a non-conjugated format. OAT3, a member of the organic anion transporter family, plays a crucial role in the renal excretion of various endogenous and exogenous compounds, including drugs and toxins. OAT3 is localized to the basolateral membrane of renal proximal tubule cells, where OAT3 facilitates the transport of organic anions from the bloodstream into the renal tubules for elimination. This function is vital for maintaining homeostasis and preventing the accumulation of harmful substances in the body. OAT3, along with OAT1, is essential for the efficient clearance of drugs such as benzylpenicillin and cimetidine, thereby influencing pharmacokinetics and drug interactions. OAT3 consists of 542 amino acids and undergoes alternative splicing, resulting in the expression of three distinct isoforms, which may have different functional properties or regulatory mechanisms. OAT3 monoclonal antibody (3C11) enables researchers to gain insights into the transport mechanisms and physiological significance of OAT3 in various species, contributing to a better understanding of renal function and drug metabolism.

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OAT3 Antibody (3C11) References:

1. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).  |  Race, JE., et al. 1999. Biochem Biophys Res Commun. 255: 508-14. PMID: 10049739
2. Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.  |  Bahn, A., et al. 2000. Biochem Biophys Res Commun. 275: 623-30. PMID: 10964714
3. Isolation of a family of organic anion transporters from human liver and kidney.  |  Sun, W., et al. 2001. Biochem Biophys Res Commun. 283: 417-22. PMID: 11327718
4. Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.  |  Vallon, V., et al. 2008. Am J Physiol Renal Physiol. 294: F867-73. PMID: 18216144
5. Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.  |  Ogasawara, K., et al. 2008. J Hum Genet. 53: 607-614. PMID: 18414781
6. Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury.  |  Zhang, R., et al. 2008. Am J Nephrol. 28: 772-83. PMID: 18441523
7. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.  |  Chen, J., et al. 2008. Am J Physiol Renal Physiol. 295: F247-52. PMID: 18480179
8. Interaction of imatinib with human organic ion carriers.  |  Hu, S., et al. 2008. Clin Cancer Res. 14: 3141-8. PMID: 18483382
9. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.  |  Hsueh, CH., et al. 2016. Mol Pharm. 13: 3130-40. PMID: 27467266
10. OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis.  |  Gao, J., et al. 2022. Biomed Pharmacother. 153: 113558. PMID: 36076621
11. Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3.  |  Chen, Y., et al. 2023. Molecules. 28: PMID: 37375294
12. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.  |  Lu, R., et al. 1999. Am J Physiol. 276: F295-303. PMID: 9950961

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OAT3 Antibody (3C11) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-OAT3 Antibody (3C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OAT3 Antibody (3C11) Specifications

Alternate Product Name: OAT3

Product Clone Name: 3C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 256-325

Epitope Target: OAT3

Epitope Species: human

Product Reactivity/Detection: OAT3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for OAT3 Antibody (3C11): N/A