Nup50 Antibody (B-6): sc-398992

Nup50 Antibody (B-6) is a mouse monoclonal IgG2a antibody that detects Nup50 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nup50, also known as NPAP60 or NPAP60L, is a crucial 468 amino acid nuclear protein that plays a significant role in the transport of macromolecules across the nuclear pore complex, serving as a binding site for export receptor-cargo complexes. Anti-Nup50 antibody (B-6) targets a protein primarily localized to the nucleoplasmic fibrils of the nuclear pore complex, where Nup50 interacts with various transport receptor proteins, including p27, facilitating the efficient movement of proteins and RNA between the nucleus and cytoplasm. The presence of multiple phenylalanine-glycine (FG) repeats and a RanBD1 domain in Nup50 is essential for function, as these structural features contribute to Nup50′s ability to mediate transport processes and maintain cellular homeostasis. Nup50 is ubiquitously expressed, with particularly high levels found in peripheral blood leukocytes, testis, and fetal liver, underscoring its importance in various biological contexts. Nup50 monoclonal antibody (B-6) is an invaluable tool for researchers studying nuclear transport mechanisms and the role of nucleoporins in cellular function.

The preferred Nup50 antibody is Nup50 Antibody (G-4): sc-398993.