NTR3 Antibody (E-9): sc-376576
- NTR3 Antibody (E-9) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 78-377 mapping within an extracellular domain of NTR3 of human origin
- recommended for detection of NTR3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for NTR3 Antibody (E-9) for WB applications. These reagents are now offered in bundles with NTR3 Antibody (E-9) (see ordering information below).
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NTR3 Antibody (E-9) is a mouse monoclonal IgG2a antibody that detects NTR3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NTR3, also known as sortilin-1 or Gp95, plays a crucial role in the central nervous system and peripheral tissues by mediating neurotensin signaling, which is essential for various physiological processes including pain modulation, thermoregulation, and metabolic control. NTR3 is primarily located in the endoplasmic reticulum and Golgi apparatus, where NTR3 undergoes post-translational modifications such as glycosylation, which are vital for proper folding, stability, and receptor activity. These modifications not only influence NTR3′s trafficking and localization but also NTR3′s interaction with neurotensin and other signaling molecules, thereby impacting downstream signaling pathways that regulate inflammatory responses and neuronal function. Anti-NTR3 antibody (E-9) is an invaluable tool for researchers investigating the complex roles of neurotensin receptors in health and disease, providing insights into their potential as therapeutic targets.
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NTR3 Antibody (E-9) References:
- Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. | Nielsen, MS., et al. 1999. J Biol Chem. 274: 8832-6. PMID: 10085125
- Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. | Navarro, V., et al. 2001. FEBS Lett. 495: 100-5. PMID: 11322955
- Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. | Navarro, V., et al. 2002. Biochem Biophys Res Commun. 298: 760-4. PMID: 12419319
- Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. | Martin, S., et al. 2003. J Neurosci. 23: 1198-205. PMID: 12598608
- Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line. | Dicou, E., et al. 2004. J Neurosci Res. 78: 92-9. PMID: 15372498
- Impairement of HT29 Cancer Cells Cohesion by the Soluble Form of Neurotensin Receptor-3. | Massa, F., et al. 2014. Genes Cancer. 5: 240-249. PMID: 25221642
- Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation. | Béraud-Dufour, S., et al. 2016. Int J Mol Sci. 17: PMID: 27834811
- Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration. | Kim, JT., et al. 2018. Neoplasia. 20: 175-181. PMID: 29272741
- Deciphering Mechanisms of Action of Sortilin/Neurotensin Receptor-3 in the Proliferation Regulation of Colorectal and Other Cancers. | Mazella, J. 2022. Int J Mol Sci. 23: PMID: 36233189
- Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. | Munck Petersen, C., et al. 1999. EMBO J. 18: 595-604. PMID: 9927419
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NTR3 Antibody (E-9) | sc-376576 | 200 µg/ml | $322.00 | |||
NTR3 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-540600 | 200 µg Ab; 10 µg BP | $361.00 | |||
NTR3 Antibody (E-9): m-IgG2a BP-HRP Bundle | sc-546934 | 200 µg Ab; 10 µg BP | $361.00 |