NTR3 Activators
NTR3 activators comprise a diverse group of chemicals that modulate the activation of NTR3 through various cellular pathways. Retinoic acid, a metabolite of vitamin A, directly activates NTR3 by binding to retinoic acid receptors, promoting neuronal differentiation. Lithium chloride indirectly activates NTR3 by inhibiting GSK-3, leading to the stabilization of β-catenin and enhanced NTR3 expression. Forskolin stimulates adenylate cyclase, increasing cAMP levels and activating NTR3 through the PKA pathway. Resveratrol, a polyphenol, indirectly activates NTR3 by modulating the SIRT1/AMPK pathway, promoting neurogenesis. Compounds like 2-Methylthioadenine influence the methionine salvage pathway, indirectly enhancing NTR3 activation and contributing to neurogenic processes. A769662, an AMPK activator, indirectly activates NTR3 by regulating cellular energy homeostasis. SB-216763 inhibits GSK-3, indirectly enhancing NTR3 activation through the Wnt pathway. P7C3-A20 exerts neuroprotective effects, indirectly supporting NTR3 activation by promoting mitochondrial function.
O-Phospho-L-serine influences serine metabolism, indirectly activating NTR3 and contributing to neuronal differentiation. AICAR activates NTR3 through AMPK signaling, fostering neurogenesis. NSI-189 influences neurogenesis and synaptic plasticity, indirectly activating NTR3. Dibutyryl-cAMP mimics cAMP effects, indirectly supporting NTR3 activation and promoting processes associated with neuronal differentiation. This diverse array of NTR3 activators acts through distinct biochemical pathways, highlighting the intricate network of cellular processes that contribute to the activation of NTR3 and, consequently, neurogenesis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, activates NTR3 by binding to retinoic acid receptors (RARs). The binding leads to the formation of a transcriptional complex, promoting the expression of genes involved in neuronal differentiation and NTR3 activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride indirectly activates NTR3 by inhibiting glycogen synthase kinase-3 (GSK-3), a negative regulator of the Wnt signaling pathway. Inhibition of GSK-3 stabilizes β-catenin, which enhances NTR3 transcription and subsequent activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates NTR3 by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates protein kinase A (PKA), which, in turn, modulates the NTR3 pathway, promoting cellular responses associated with neuronal differentiation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, indirectly activates NTR3 by modulating the SIRT1/AMPK pathway. Activation of SIRT1 by resveratrol influences downstream AMPK signaling, culminating in the activation of NTR3 and promotion of neurogenic processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMP-activated protein kinase (AMPK) activator, indirectly activates NTR3 by regulating energy homeostasis. AMPK activation by A769662 promotes NTR3-mediated neurogenesis through modulation of cellular energy status and metabolic pathways. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 activates NTR3 by inhibiting GSK-3, a negative regulator of the Wnt pathway. By preventing GSK-3-mediated degradation of β-catenin, SB-216763 indirectly enhances NTR3 activation, contributing to neuronal differentiation and neurogenic processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates NTR3 by activating AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. The modulation of AMPK signaling by AICAR indirectly supports NTR3 activation, promoting neurogenic processes and neuronal differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP activates NTR3 by mimicking the effects of cAMP, a second messenger in cellular signaling. The compound, by elevating intracellular cAMP levels, indirectly supports NTR3 activation, fostering neurogenesis and processes associated with neuronal differentiation. | ||||||