NSD3 Antibody (H-8): sc-271839
- NSD3 Antibody (H-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 319-618 mapping within an internal region of NSD3 of human origin
- recommended for detection of NSD3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NSD3 Antibody (H-8) for WB applications. These reagents are now offered in bundles with NSD3 Antibody (H-8) (see ordering information below).
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NSD3 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects NSD3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NSD3 is a crucial protein involved in the regulation of gene expression and chromatin remodeling, playing a significant role in various cellular processes, including development and differentiation. NSD3 is primarily located in the nucleus, where NSD3 interacts with chromatin and other nuclear proteins to modulate transcriptional activity. This nuclear localization allows NSD3 to influence the epigenetic landscape, thereby affecting gene expression patterns essential for normal cellular function and response to environmental signals. NSD3 contains multiple functional domains, including PWWP and PHD-type zinc finger motifs, which facilitate interactions with other proteins and chromatin, underscoring NSD3′s importance in maintaining cellular homeostasis and regulating developmental pathways. NSD3 expression is notably high in brain, heart, and skeletal muscle tissues, indicating potential involvement in the physiological functions of these organs, while lower levels in the liver and lungs suggest a more specialized role in these tissues.
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NSD3 Antibody (H-8) References:
- NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. | French, CA., et al. 2014. Cancer Discov. 4: 928-41. PMID: 24875858
- NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. | Shen, C., et al. 2015. Mol Cell. 60: 847-59. PMID: 26626481
- Silencing of histone methyltransferase NSD3 reduces cell viability in osteosarcoma with induction of apoptosis. | Liu, Z., et al. 2017. Oncol Rep. 38: 2796-2802. PMID: 28901481
- Protective effect of histone methyltransferase NSD3 on ISO-induced cardiac hypertrophy. | Chen, K., et al. 2019. FEBS Lett. 593: 2556-2565. PMID: 31254363
- Profiling NSD3-dependent neural crest gene expression reveals known and novel candidate regulatory factors. | Jacques-Fricke, BT., et al. 2021. Dev Biol. 475: 118-130. PMID: 33705737
- Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase. | Sun, Y., et al. 2022. Eur J Med Chem. 239: 114528. PMID: 35717870
- Dissecting the Immunological Profiles in NSD3-Amplified LUSC through Integrative Multi-Scale Analyses. | Xu, D., et al. 2022. Cancers (Basel). 14: PMID: 36291782
- Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain. | Kim, S., et al. 2023. Chem Biol Drug Des. 102: 500-513. PMID: 37072259
- The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading at mitotic exit. | Eot-Houllier, G., et al. 2023. J Cell Sci. 136: PMID: 37288770
- Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation. | Shipman, GA., et al. 2024. Genome Biol. 25: 263. PMID: 39390582
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSD3 Antibody (H-8) | sc-271839 | 200 µg/ml | $322.00 | |||
NSD3 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-540267 | 200 µg Ab; 10 µg BP | $361.00 | |||
NSD3 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-542013 | 200 µg Ab; 20 µg BP | $361.00 |