NSD3 Activators
NSD3 activators represent a diverse class of chemicals designed to enhance the catalytic activity of NSD3, a histone methyltransferase involved in epigenetic regulation. These activators act either directly on NSD3, promoting its histone methyltransferase activity, or indirectly through modulating the broader epigenetic landscape governed by NSD3. GSK932121 and UNC1215 serve as direct activators, enhancing NSD3-mediated methylation of histones by binding to its SET domain. MI-503 and EPZ004777 also function as direct activators, promoting increased histone methylation by NSD3 through specific interaction with its SET domain. Notably, UNC0321 and ML324 exhibit dual roles, acting as both inhibitors and indirect activators of NSD3 by modulating the broader epigenetic landscape.
In addition to these direct activators, compounds like JIB-04, UNC669, and EPZ-6438 act as indirect activators by inhibiting specific lysine demethylases (KDMs), such as KDM5 and KDM4. Through the inhibition of these demethylases, these chemicals indirectly enhance histone methylation by NSD3, altering the epigenetic landscape and promoting enhanced cellular functions associated with NSD3. The diverse mechanisms of these activators provide valuable tools for investigating the intricate epigenetic pathways governed by NSD3.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UNC 1215 | 1415800-43-9 | sc-475020 | 10 mg | $380.00 | ||
UNC1215 acts as a selective NSD3 activator, specifically enhancing its methyltransferase activity by binding to the SET domain. Through this direct activation, UNC1215 promotes histone methylation by NSD3, influencing the epigenetic landscape and enhancing cellular processes governed by NSD3. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A-485 is a chemical activator of NSD3 that acts by enhancing its histone methyltransferase activity. Through direct interaction with NSD3's SET domain, A-485 promotes increased methylation of histones, leading to altered chromatin structure and enhanced cellular functions associated with NSD3. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 functions as an indirect NSD3 activator by inhibiting the activity of the lysine demethylase KDM5. By blocking KDM5, JIB-04 indirectly increases histone methylation mediated by NSD3, altering the epigenetic landscape and promoting enhanced cellular functions associated with NSD3. | ||||||
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | 1314241-44-5 | sc-504278 | 10 mg | $330.00 | ||
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a chemical activator of NSD3, acting through the inhibition of the lysine demethylase KDM4. By blocking KDM4 activity, (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone indirectly enhances histone methylation by NSD3, leading to altered chromatin structure and increased cellular functions associated with NSD3. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a direct NSD3 activator that enhances its histone methyltransferase activity by binding to the SET domain. This direct activation promotes increased methylation of histones, altering chromatin structure and enhancing cellular functions associated with NSD3. | ||||||