NPRL2 Antibody (H-8): sc-166969

NPRL2 Antibody (H-8) is a mouse monoclonal IgG2b antibody that detects NPRL2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein characterized by a bipartite nuclear localization signal and a granulin protein-binding domain, which are crucial for its function in cellular processes. NPRL2 is predominantly expressed in skeletal muscle, with significant levels also found in the brain, liver, and pancreas, while lower expression is noted in the lung, kidney, placenta, and heart. NPRL2 is particularly relevant in the context of cancer, as NPRL2 is expressed in most lung cancer cell lines and is believed to play a role in tumor suppression, mismatch repair, and cell cycle checkpoint signaling. Notably, NPRL2 may enhance the therapeutic efficacy of chemotherapy drugs, such as cisplatin, by resensitizing patients who have developed resistance to this treatment. The gene encoding NPRL2 is conserved across species and produces two isoforms due to alternative splicing, highlighting its evolutionary significance and potential as a target for therapeutic intervention. Anti-NPRL2 antibody (H-8) is an essential tool for researchers investigating the molecular mechanisms underlying cancer biology and therapeutic resistance.

The preferred NPRL2 antibody is NPRL2 Antibody (F-3): sc-376986.