NPR-C Antibody (B-9): sc-515749

NPR-C Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects NPR-C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NPR-C, also known as the clearance receptor, plays a crucial role in regulating natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Located primarily in kidneys and vascular tissues, NPR-C is essential for maintaining cardiovascular and renal homeostasis by clearing these peptides from circulation, thus preventing excessive vasodilation and natriuresis. NPR-C′s ability to modulate natriuretic peptide levels is vital for controlling blood pressure and fluid balance, making NPR-C a significant player in the pathophysiology of conditions such as hypertension and heart failure. Anti-NPR-C antibody (B-9) enables researchers to gain insights into functional dynamics of NPR-C and implications in various cardiovascular and renal diseases, potentially paving the way for novel therapeutic strategies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NPR-C Antibody (B-9) References:

1. Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells.  |  Sun, JZ., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 281: L155-63. PMID: 11404258
2. Cyclic adenosine monophosphate (cAMP) increases natriuretic peptide receptor C (NPR-C) expression in human aortic smooth muscle cells.  |  Puggina, E. and Sellitti, D. 2004. Mol Cell Endocrinol. 219: 161-9. PMID: 15149737
3. Identification, regulation and anti-proliferative role of the NPR-C receptor in gastric epithelial cells.  |  Gower, WR., et al. 2006. Mol Cell Biochem. 293: 103-18. PMID: 16786190
4. C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreas.  |  Sabbatini, ME., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 293: G987-94. PMID: 17702953
5. Stimulatory and Inhibitory regulation of lipolysis by the NPR-A/cGMP/PKG and NPR-C/G(i) pathways in rat cultured adipocytes.  |  Nishikimi, T., et al. 2009. Regul Pept. 153: 56-63. PMID: 19027799
6. NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina.  |  Abdelalim, EM. and Tooyama, I. 2010. Peptides. 31: 180-3. PMID: 19878700
7. Upregulation of ANP and NPR-C mRNA in the kidney and heart of eNOS knockout mice.  |  Yuan, K., et al. 2010. Peptides. 31: 1319-25. PMID: 20403400
8. NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels.  |  Abdelalim, EM. and Tooyama, I. 2012. Stem Cells Dev. 21: 1264-71. PMID: 21846177
9. Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C).  |  Moghtadaei, M., et al. 2017. Sci Rep. 7: 17564. PMID: 29242602
10. Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta.  |  LaDisa, JF., et al. 2019. Physiol Genomics. 51: 177-185. PMID: 31002586

The preferred NPR-C antibody is NPR-C Antibody (E-5): sc-515449.