NPR-C Antibody (E-5): sc-515449

NPR-C Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects NPR-C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NPR-C (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NPR-C protein, also known as the clearance receptor, plays a crucial role in regulating natriuretic peptides, which are vital for maintaining cardiovascular, renal, and endocrine homeostasis. These peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), interact with NPR-C to modulate their physiological effects. NPR-C is responsible for clearing these peptides from circulation, thereby regulating their levels and preventing excessive signaling that could lead to pathological conditions. NPR-C plays a significant role in various diseases, including hypertension, congestive heart failure, and renal disorders, where natriuretic peptide system dysregulation is commonly observed. Using anti-NPR-C antibody (E-5) in research can provide valuable insights into these conditions and help explore potential therapeutic targets within the natriuretic peptide signaling pathway.

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NPR-C Antibody (E-5) References:

1. Development of p-benzoylbenzoylated [N,C,rANP(1-28)]pBNP32 (pBNP1) derivatives and affinity photolabeling of the bovine NPR-A receptor.  |  Coupal, M., et al. 1999. Biochem Biophys Res Commun. 258: 81-6. PMID: 10222239
2. The natriuretic peptides in heart failure: diagnostic and therapeutic potentials.  |  Chen, HH. and Burnett, JC. 1999. Proc Assoc Am Physicians. 111: 406-16. PMID: 10519161
3. Guanylyl cyclase-B represents the predominant natriuretic peptide receptor expressed at exceptionally high levels in the pineal gland.  |  Müller, D., et al. 2000. Brain Res Mol Brain Res. 75: 321-9. PMID: 10686354
4. Natriuretic peptides in the pathophysiology of congestive heart failure.  |  Chen, HH. and Burnett, JC. 2000. Curr Cardiol Rep. 2: 198-205. PMID: 10980893
5. A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C.  |  He, XL., et al. 2005. Peptides. 26: 1035-43. PMID: 15911071
6. NPR-C: a component of the natriuretic peptide family with implications in human diseases.  |  Rubattu, S., et al. 2010. J Mol Med (Berl). 88: 889-97. PMID: 20563546
7. NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.  |  Jansen, HJ., et al. 2019. Circ Arrhythm Electrophysiol. 12: e006863. PMID: 30636477
8. Role of epicardial adipose tissue NPR-C in acute coronary syndrome.  |  Moreno-Santos, I., et al. 2019. Atherosclerosis. 286: 79-87. PMID: 31102956
9. Natriuretic Peptide Clearance Receptor (NPR-C) Pathway as a Novel Therapeutic Target in Obesity-Related Heart Failure With Preserved Ejection Fraction (HFpEF).  |  Egom, EEA. 2021. Front Physiol. 12: 674254. PMID: 34093235
10. [Molecular biology and pharmacology of natriuretic peptide system].  |  Itoh, H., et al. 1993. Nihon Rinsho. 51: 1548-56. PMID: 8100590
11. Atrial natriuretic peptide-C receptor and membrane signalling in hypertension.  |  Anand-Srivastava, MB. 1997. J Hypertens. 15: 815-26. PMID: 9280203
12. [Natriuretic peptide system].  |  Itoh, H. and Nakao, K. 1997. Nihon Rinsho. 55: 1923-36. PMID: 9284403

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NPR-C Antibody (E-5) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-NPR-C Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NPR-C Antibody (E-5) Specifications

Alternate Product Name: NPR-C

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 141-440

Epitope Target: NPR-C

Epitope Species: human

Product Reactivity/Detection: NPR-C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for NPR-C Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin