NOXA Antibody (114C307): sc-56169

NOXA Antibody (114C307) is a mouse monoclonal IgG1 kappa light chain antibody that detects NOXA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-NOXA antibody (114C307) is available as the non-conjugated form. NOXA protein, also known as PMA-induced protein 1 or APR, plays a critical role in regulating apoptosis, a vital process for maintaining cellular homeostasis and eliminating damaged or unwanted cells. As a pro-apoptotic member of the Bcl-2 family, NOXA selectively localizes to mitochondria, where NOXA interacts with other Bcl-2 family proteins to promote cell death in response to various stress signals, including DNA damage. This localization enables NOXA to effectively mediate the mitochondrial pathway of apoptosis, which is often dysregulated in cancer and other diseases. In murine cells, NOXA mRNA is constitutively expressed in small amounts across various organs, and expression can be significantly upregulated by X-ray irradiation, highlighting NOXA′s role in cellular responses to stress. In human cells, particularly in the adult T cell leukemia cell line IKD, NOXA is expressed at high levels, suggesting involvement in tumorigenesis and as an immediate-early-response gene. NOXA′s ability to modulate apoptosis underscores importance in both normal physiological processes and pathological conditions, making NOXA (114C307) antibody a valuable tool for researchers studying cell death mechanisms and their implications in disease.

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NOXA Antibody (114C307) References:

1. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.  |  Oda, E., et al. 2000. Science. 288: 1053-8. PMID: 10807576
2. Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460.  |  Voortman, J., et al. 2007. Mol Cancer Ther. 6: 1046-53. PMID: 17363497
3. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.  |  Hockenbery, DM., et al. 1991. Proc Natl Acad Sci U S A. 88: 6961-5. PMID: 1871110
4. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.  |  Nuñez, G., et al. 1990. J Immunol. 144: 3602-10. PMID: 2184193
5. Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line.  |  Hijikata, M., et al. 1990. J Virol. 64: 4632-9. PMID: 2398525
6. Noxa: Role in Cancer Pathogenesis and Treatment.  |  Morsi, RZ., et al. 2018. Curr Cancer Drug Targets. 18: 914-928. PMID: 29521234
7. 5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.  |  Jin, S., et al. 2020. Clin Cancer Res. 26: 3371-3383. PMID: 32054729
8. BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis.  |  Roufayel, R., et al. 2022. Life (Basel). 12: PMID: 35207544
9. Induction of apoptosis by the Bcl-2 homologue Bak.  |  Chittenden, T., et al. 1995. Nature. 374: 733-6. PMID: 7715730
10. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak.  |  Kiefer, MC., et al. 1995. Nature. 374: 736-9. PMID: 7715731
11. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.  |  Oltvai, ZN., et al. 1993. Cell. 74: 609-19. PMID: 8358790
12. The Bcl-2 protein family: arbiters of cell survival.  |  Adams, JM. and Cory, S. 1998. Science. 281: 1322-6. PMID: 9735050

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NOXA Antibody (114C307) has 58 citations in a variety of scientific publications.

Primary antibodies like Anti-NOXA Antibody (114C307) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NOXA Antibody (114C307) Specifications

Alternate Product Name: NOXA

Product Clone Name: 114C307

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NOXA

Epitope Species: human

Product Reactivity/Detection: NOXA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 58 citations in various scientific publications

Available Conjugates/Forms for NOXA Antibody (114C307): N/A

The preferred NOXA antibody is NOXA Antibody (F-3): sc-515840.