NOSTRIN Antibody (F-4): sc-365296

NOSTRIN Antibody (F-4) is a mouse monoclonal IgG2b antibody that detects NOSTRIN in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NOSTRIN, also known as nitric oxide synthase trafficker isoform 1, plays a crucial role in the vascular system by facilitating the transport of endothelial nitric oxide synthase (NOS3), which is essential for the production of nitric oxide (NO), a key signaling molecule involved in numerous physiological processes such as vasodilation and blood flow regulation. NOSTRIN is predominantly expressed in vascular endothelial cells of highly vascularized tissues, including the placenta, lung, kidney, and heart, where NOSTRIN forms a trimeric structure composed of an N-terminal Cdc15 domain, an FCH region, two coiled-coil domains, and a C-terminal SH3 domain. NOSTRIN′s ability to bind to caveolin-1 and NOS3 allows NOSTRIN to form a ternary complex that is vital for the caveolar transport of NOS3, thereby influencing NO production. Additionally, NOSTRIN interacts with other proteins such as Dynamin and N-WASP, which further underscores NOSTRIN′s importance in cellular signaling and transport mechanisms. Anti-NOSTRIN antibody (F-4) is an invaluable tool for researchers studying the dynamics of nitric oxide signaling and its implications in vascular biology and related diseases.

The preferred NOSTRIN antibody is NOSTRIN Antibody (B-9): sc-373954.