Nop14 Antibody (C-3): sc-398724

Nop14 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects Nop14 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nop14, also known as nucleolar protein 14 or NOL14, is a crucial 857 amino acid nuclear protein that plays a significant role in the processing of pre-18S ribosomal RNA within the nucleolus, which is essential for the formation of ribosomes, the cellular machinery responsible for protein synthesis. Proper functioning of Nop14 is vital, as any disruption in ribosomal RNA processing can lead to impaired protein synthesis and has been linked to various diseases, including cancer and genetic disorders. Additionally, Nop14 is involved in the nuclear export of the 40S pre-ribosomal subunit to the cytoplasm, further emphasizing Nop14′s importance in ribosome biogenesis. The gene encoding Nop14 is located on human chromosome 4p16.3, a region that harbors nearly 900 genes and is associated with several genetic conditions, including Huntington′s disease and achondroplasia. Nop14 (C-3) antibody is an invaluable tool for researchers studying ribosome assembly and related cellular processes, providing insights into the molecular mechanisms underlying various diseases.

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Nop14 Antibody (C-3) References:

1. NOP14 promotes proliferation and metastasis of pancreatic cancer cells.  |  Zhou, B., et al. 2012. Cancer Lett. 322: 195-203. PMID: 22425761
2. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.  |  Lei, JJ., et al. 2015. Oncotarget. 6: 25701-14. PMID: 26213846
3. A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.  |  Suzuki, T., et al. 2018. J Hum Genet. 63: 425-430. PMID: 29440706
4. NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.  |  Li, J., et al. 2018. Braz J Med Biol Res. 52: e7952. PMID: 30484495
5. LncRNA NOP14-AS1 Promotes Tongue Squamous Cell Carcinoma Progression by Targeting MicroRNA-665/HMGB3 Axis.  |  Li, J., et al. 2021. Cancer Manag Res. 13: 2821-2834. PMID: 33814931
6. NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.  |  Zhu, X., et al. 2021. Eur J Histochem. 65: PMID: 34218653
7. The NOP14 nucleolar protein suppresses the function and stemness of melanoma stem-like cells through Wnt/beta-catenin signaling inactivation.  |  Li, J., et al. 2022. Bioengineered. 13: 7648-7658. PMID: 35282769
8. Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.  |  Lu, C., et al. 2022. BMC Gastroenterol. 22: 207. PMID: 35473611
9. NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.  |  Yan, X., et al. 2024. J Biol Chem. 300: 105681. PMID: 38272224
10. NOP14 as a Potential Predictor of Adult-Type Diffuse Glioma Prognosis and Immunotherapy, is Related to Cell Migration, Proliferation, and CD8+T Cell Infiltration.  |  Tian, QS., et al. 2024. Front Biosci (Landmark Ed). 29: 104. PMID: 38538274

The preferred Nop14 antibody is Nop14 Antibody (B-5): sc-398763.