NMDAζ1 Antibody (E-2): sc-518043
- NMDAζ1 Antibody (E-2) is a mouse monoclonal IgG2b κ NMDAζ1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 654-680 within an internal region of NMDAζ1 of human origin
- NMDA zeta 1 Antibody (E-2) is recommended for detection of NMDAζ1 of human origin by WB, IP, IF and ELISA
- Anti-NMDA zeta 1 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NMDAζ1 Antibody (E-2) for WB applications. These reagents are now offered in bundles with NMDAζ1 Antibody (E-2) (see ordering information below).
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NMDAζ1 Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects NMDA zeta 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NMDAζ1 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NMDA zeta 1 protein, also known as glutamate ionotropic receptor NMDA type subunit 1, plays a crucial role in mediating excitatory neurotransmission in the brain, which is essential for processes such as learning, memory, and synaptic plasticity. NMDA zeta 1 is primarily located in the postsynaptic membrane of neurons, where NMDA zeta 1 forms part of the NMDA receptor complex, allowing for calcium ion influx in response to glutamate binding. The unique structure of NMDA receptors, which includes a high permeability to calcium ions, is vital for their function in synaptic signaling and plasticity, as calcium influx activates various intracellular signaling pathways that influence neuronal function and survival. Understanding NMDA receptors in synaptic transmission and their involvement in neurodegenerative diseases highlights the significance of anti-NMDA zeta 1 antibody (E-2) in research aimed at unraveling the complexities of brain function and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NMDAζ1 Antibody (E-2) References:
- Modulation of the channel activity of the epsilon2/zeta1-subtype N-methyl D-aspartate receptor by PSD-95. | Yamada, Y., et al. 1999. J Biol Chem. 274: 6647-52. PMID: 10037761
- Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex. | Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
- Molecular diversity of glutamate receptors and implications for brain function. | Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
- The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. | Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
- Downregulation of N-methyl-D-aspartate receptor ζ1 subunit (GluN1) gene in inferior colliculus with aging. | Osumi, Y., et al. 2012. Brain Res. 1454: 23-32. PMID: 22483791
- Systematic analysis to identify novel disease indications and plausible potential chemical leads of glutamate ionotropic receptor NMDA type subunit 1, GRIN1. | Bhardwaj, T., et al. 2023. J Mol Recognit. 36: e2997. PMID: 36259267
- Glutamate ionotropic receptor NMDA type subunit 1: A novel potential protein target of dapagliflozin against renal interstitial fibrosis. | Liu, Y., et al. 2023. Eur J Pharmacol. 943: 175556. PMID: 36736528
- Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem. | Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
- Cloned glutamate receptors. | Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
- A synaptic model of memory: long-term potentiation in the hippocampus. | Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
- Differential expression and co-assembly of NMDA zeta 1 and epsilon subunits in the mouse cerebellum during postnatal development. | Didier, M., et al. 1995. Neuroreport. 6: 2255-9. PMID: 8595214
- Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. | Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NMDAζ1 Antibody (E-2) | sc-518043 | 200 µg/ml | $322.00 | |||
NMDAζ1 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-525337 | 200 µg Ab, 40 µg BP | $361.00 | |||
NMDAζ1 Antibody (E-2): m-IgG2b BP-HRP Bundle | sc-549230 | 200 µg Ab; 10 µg BP | $361.00 | |||
NMDAζ1 Antibody (E-2) AC | sc-518043 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NMDAζ1 Antibody (E-2) HRP | sc-518043 HRP | 200 µg/ml | $322.00 | |||
NMDAζ1 Antibody (E-2) FITC | sc-518043 FITC | 200 µg/ml | $336.00 | |||
NMDAζ1 Antibody (E-2) PE | sc-518043 PE | 200 µg/ml | $349.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 488 | sc-518043 AF488 | 200 µg/ml | $364.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 546 | sc-518043 AF546 | 200 µg/ml | $364.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 594 | sc-518043 AF594 | 200 µg/ml | $364.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 647 | sc-518043 AF647 | 200 µg/ml | $364.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 680 | sc-518043 AF680 | 200 µg/ml | $364.00 | |||
NMDAζ1 Antibody (E-2) Alexa Fluor® 790 | sc-518043 AF790 | 200 µg/ml | $364.00 |