NMDAε2 Antibody (A-8): sc-365597

NMDAε2 Antibody (A-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects the NMDA epsilon 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-NMDAε2 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The NMDA epsilon 2 protein, also known as GRIN2B, plays a crucial role in synaptic plasticity and memory function, as GRIN2B is a key component of the NMDA receptor, which is essential for mediating excitatory neurotransmission in the central nervous system. This receptor is unique due to voltage-dependent activation and high permeability to calcium ions, which are vital for various intracellular signaling pathways. The NMDA receptor is composed of multiple subunits, including ε1, ε2, ε3, ε4, and a ζ subunit, with the ε2 subunit being particularly important for receptor assembly and function. Proper functioning of NMDA receptors is critical for processes such as learning and memory, and dysregulation of these receptors has been implicated in several neurological disorders, including Alzheimer′s disease, schizophrenia, and epilepsy. NMDAε2 monoclonal antibody (A-8) serves as a valuable tool for researchers investigating the role of NMDA receptors in health and disease.

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NMDAε2 Antibody (A-8) References:

1. Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.  |  Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
2. Molecular diversity of glutamate receptors and implications for brain function.  |  Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
3. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.  |  Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
4. Human GRIN2B variants in neurodevelopmental disorders.  |  Hu, C., et al. 2016. J Pharmacol Sci. 132: 115-121. PMID: 27818011
5. GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.  |  Platzer, K., et al. 2017. J Med Genet. 54: 460-470. PMID: 28377535
6. Distinct roles of GRIN2A and GRIN2B variants in neurological conditions.  |  Myers, SJ., et al. 2019. F1000Res. 8: PMID: 31807283
7. Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b.  |  Sheng, Z., et al. 2022. Br J Anaesth. 129: 544-554. PMID: 35697546
8. Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology.  |  Korinek, M., et al. 2024. Physiol Res. 73: S413-S434. PMID: 38836461
9. Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.  |  Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
10. Cloned glutamate receptors.  |  Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
11. A synaptic model of memory: long-term potentiation in the hippocampus.  |  Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
12. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate.  |  Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NMDAε2 Antibody (A-8) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-NMDAε2 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NMDAε2 Antibody (A-8) Specifications

Alternate Product Name: GRIN2B

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 27-76

Epitope Target: NMDAε2

Epitope Species: human

Product Reactivity/Detection: glutamate (NMDA) receptor subtype epsilon 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for NMDAε2 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin