NKHC1 Antibody (G-1): sc-374666

NKHC1 Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects NKHC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NKHC1, also known as KIF5A or kinesin family member 5A, plays a crucial role as a neuronal-specific component of a multi-subunit molecular motor complex responsible for intracellular organelle transport, which is vital for maintaining neuronal function and health. Mutations in the gene encoding NKHC1 are linked to autosomal dominant spastic paraplegia 10, a neurodegenerative disorder characterized by progressive weakness and stiffness of the legs. NKHC1 exhibits a pan-neuronal distribution within the nervous system, with presence confirmed in brain and sciatic nerve tissues, where NKHC1 forms a characteristic doublet in immunoblot analyses. Within cultured hippocampal neurons, NKHC1 is notably concentrated in the perinuclear region of the cell body, highlighting its role in the transport of essential cellular components. As a member of the kinesin superfamily, NKHC1 is integral to the movement of cargo along microtubules, ensuring that vital materials are delivered to their appropriate locations within the neuron, thereby supporting overall cellular function and integrity.

The preferred NKHC1 antibody is NKHC1 Antibody (C-11): sc-376452.