nitrated alpha/beta Synuclein Antibody (Syn12): sc-32278

nitrated α/β-synuclein Antibody (Syn12) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect nitrated forms of α-synuclein and β-synuclein proteins in human samples. nitrated α/β-synuclein monoclonal antibody (Syn12) targets an epitope on recombinant human α-synuclein that has been nitrated in vitro, making anti-nitrated α/β-synuclein antibody (Syn12) suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. α-Synuclein, also known as NACP, and β-synuclein, designated as PNP 14, are presynaptic proteins predominantly expressed in the brain, where they play crucial roles in synaptic regulation and neuronal plasticity. Nitration is a significant post-translational modification of α-synuclein that is implicated in the pathogenesis of neurodegenerative diseases like Parkinson′s disease, as nitration affects protein aggregation and toxicity. α-Synuclein interacts with several key proteins, including synphilin-1, which contributes to the formation of Lewy bodies, and Parkin, an E3 ubiquitin ligase involved in protein degradation pathways. β-Synuclein interacts with proteins such as tau, which is important in Alzheimer′s disease, highlighting β-synuclein′s role in neuronal health. Nitration of these synucleins alters interactions with binding partners, thereby influencing function and contributing to disease progression. nitrated α/β-synuclein (Syn12) antibody is available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP) and Alexa Fluor® conjugates, providing flexibility for different experimental needs. By specifically recognizing nitrated synucleins, nitrated α/β-synuclein (Syn12) monoclonal antibody serves as an essential tool for researchers investigating molecular mechanisms underlying synaptic dysfunction and development of neurodegenerative disorders.

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.