Nidogen-2 Antibody (F-2): sc-377424

Nidogen-2 Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects Nidogen-2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Nidogen-2 is a crucial component of the extracellular matrix, specifically found in basement membranes, where Nidogen-2 plays a vital role in cell adhesion and tissue organization. This glycoprotein undergoes nitrogen and oxygen glycosylation, which influences interactions with other matrix components and affects cellular signaling pathways. Nidogen-2 appears in diverse tissues such as the heart, placenta, and bone, highlighting Nidogen-2′s importance in maintaining structural integrity and facilitating communication between cells and their environment. Nidogen-2 interacts with other key proteins, including Laminin and Collagen IV, which are essential for stabilizing the basement membrane and supporting embryonic development. Nidogen-2′s unique structure, characterized by three globular domains, enables effective bridging of these interactions, making Nidogen-2 a critical player in both developmental processes and tissue homeostasis.

The preferred Nidogen-2 antibody is Nidogen-2 Antibody (A-7): sc-373859.