NHE-1 Antibody (C-7): sc-518042
- NHE-1 Antibody (C-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 42-61 near the N-terminus of NHE-1 of human origin
- recommended for detection of NHE-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NHE-1 Antibody (C-7) for WB applications. These reagents are now offered in bundles with NHE-1 Antibody (C-7) (see ordering information below).
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NHE-1 (C-7) is a mouse monoclonal IgG1 antibody. Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins expressed in most mammalian tissues, where these proteins regulate intracellular pH and cell volume. NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). NHE-1 shows ubiquitous expression, while NHE-2-6 isoforms have distinct tissue- and cell type-dependent expression and inhibitory characteristics by amiloride analogs. Human NHE-1, also known as solute carrier family 9 isoform-1 (SLC9A1), is a ten transmembrane domain-spanning receptor containing an N-terminal amphiphatic domain and two putative N-glycosylation sites.
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NHE-1 Antibody (C-7) References:
- Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. | Touret, N., et al. 2003. Eur J Pharmacol. 459: 151-8. PMID: 12524140
- Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways. | Stanbouly, S., et al. 2008. J Pharmacol Exp Ther. 327: 105-13. PMID: 18650245
- Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart. | Garciarena, CD., et al. 2009. J Appl Physiol (1985). 106: 1325-31. PMID: 19179646
- NHE-1 and β1 integrin dependent monocyte adhesion and migration after glucose, insulin or PPARγ stimulation. | Zolota, Z., et al. 2011. Cell Adh Migr. 5: 258-65. PMID: 21339703
- Silencing of NHE-1 blunts the slow force response to myocardial stretch. | Pérez, NG., et al. 2011. J Appl Physiol (1985). 111: 874-80. PMID: 21659487
- NHE-1 blockade reversed changes in calcium transient in myocardial slices from isoproterenol-induced hypertrophied rat left ventricle. | Hattori, H., et al. 2012. Biochem Biophys Res Commun. 419: 431-5. PMID: 22366089
- Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1. | Correa, MV., et al. 2014. Pflugers Arch. 466: 1819-30. PMID: 24327206
- An Inhibitor of the Sodium-Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia. | Kang, BS., et al. 2020. Int J Mol Sci. 21: PMID: 32545865
- Regulation of NHE-1 promoter in mammalian myocardium. | Yang, W., et al. 1996. Am J Physiol. 270: H259-66. PMID: 8769760
- Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. | Dudeja, PK., et al. 1996. Am J Physiol. 271: G483-93. PMID: 8843774
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NHE-1 Antibody (C-7) | sc-518042 | 200 µg/ml | $316.00 | |||
NHE-1 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-541117 | 200 µg Ab; 10 µg BP | $354.00 | |||
NHE-1 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-542593 | 200 µg Ab; 20 µg BP | $354.00 |