Date published: 2026-1-9

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NHE-1 Antibodies

Santa Cruz Biotechnology offers a broad range of NHE-1 monoclonal antibodies for research focused on understanding sodium-hydrogen exchanger 1 (NHE-1) protein function. NHE-1 monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). NHE-1 plays a vital role in maintaining cellular pH and volume by regulating sodium and hydrogen ion exchange across the plasma membrane. The sodium-hydrogen exchanger 1 protein is fundamental for numerous physiological processes, including cell proliferation, migration, and response to stress. Research has shown that NHE-1 dysfunction is associated with various pathological conditions, highlighting its significance as a therapeutic target. Understanding NHE-1 expression and activity patterns can provide valuable insights into cellular homeostasis mechanisms. Investigating NHE-1's role in different tissue types helps reveal its diverse biological functions. Studying NHE-1 regulation contributes to our understanding of pH-dependent cellular processes. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific knowledge about NHE-1's role in health and disease.

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NHE-1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

NHE-1 Antibody (54)

sc-136239mouse IgG1 κ682-801 (r)WB, IP, IFm, r, h
47
(5)

NHE-1 Antibody (B-12)

sc-515950mouse IgG1 κ656-815 (h)WB, IP, IF, ELISAh
1
(0)

NHE-1 Antibody (A-2)

sc-518041mouse IgG1 κ42-61 (h)WB, IP, IF, ELISAm, r, h
1
(1)

NHE-1 Antibody (C-7)

sc-518042mouse IgG1 κ42-61 (h)WB, IP, IF, ELISAm, r, h

new

(1)

NHE-1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NHE-1 CRISPR/Cas9 KO Plasmid (h)

sc-400748hGene KnockoutGFP0
(0)

NHE-1 HDR Plasmid (h)

sc-400748-HDRhHomology Directed RepairPuromycin0
(0)

NHE-1 Double Nickase Plasmid (h)

sc-400748-NIChGene KnockoutPuromycin0
(0)

NHE-1 Double Nickase Plasmid (h2)

sc-400748-NIC-2hGene KnockoutPuromycin0
(0)

NHE-1 CRISPR/Cas9 KO Plasmid (m)

sc-423015mGene KnockoutGFP0
(0)

NHE-1 HDR Plasmid (m)

sc-423015-HDRmHomology Directed RepairPuromycin0
(0)

NHE-1 Double Nickase Plasmid (m)

sc-423015-NICmGene KnockoutPuromycin0
(0)

NHE-1 Double Nickase Plasmid (m2)

sc-423015-NIC-2mGene KnockoutPuromycin0
(0)

NHE-1 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NHE-1 CRISPR Activation Plasmid (h)

sc-400748-ACThGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 CRISPR Activation Plasmid (h2)

sc-400748-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 Lentiviral Activation Particles (h)

sc-400748-LAChGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 Lentiviral Activation Particles (h2)

sc-400748-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 CRISPR Activation Plasmid (m)

sc-423015-ACTmGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 CRISPR Activation Plasmid (m2)

sc-423015-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 Lentiviral Activation Particles (m)

sc-423015-LACmGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 Lentiviral Activation Particles (m2)

sc-423015-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

NHE-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

NHE-1 siRNA (h)

sc-42650hGene SilencingN/A
4
(0)

NHE-1 shRNA Plasmid (h)

sc-42650-SHhGene SilencingPuromycin
4
(0)

NHE-1 shRNA (h) Lentiviral Particles

sc-42650-VhGene SilencingPuromycin
4
(0)

NHE-1 siRNA (m)

sc-42651mGene SilencingN/A0
(0)

NHE-1 shRNA Plasmid (m)

sc-42651-SHmGene SilencingPuromycin0
(0)

NHE-1 shRNA (m) Lentiviral Particles

sc-42651-VmGene SilencingPuromycin0
(0)