Neutrophil Elastase Antibody (201): sc-59335

Neutrophil Elastase Antibody (201) is a mouse monoclonal IgM antibody developed to target the full-length native Neutrophil Elastase (NE) of human origin. Anti-Neutrophil Elastase antibody (201) effectively recognizes NE, also known as ELANE or medullasin, through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Neutrophil Elastase is a serine protease predominantly stored within the azurophilic granules of neutrophils, a critical aspect that ensures controlled release during immune responses to prevent unintended tissue damage. Upon activation, NE is released into the extracellular matrix where NE plays a vital role in degrading extracellular matrix proteins like elastin, proteoglycans, and Type IV collagen, facilitating processes such as phagocytosis, neutrophil migration, and tissue remodeling following injury. Additionally, NE is involved in the modulation of the complement system by cleaving proteins such as antithrombin and fibrinogen, and acts as a potent platelet agonist, enhancing platelet aggregation, secretion, and calcium mobilization. The precise detection of Neutrophil Elastase by Neutrophil Elastase monoclonal antibody (201) makes this product an indispensable tool for researchers studying inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome, and cystic fibrosis. By providing reliable and specific binding to human NE, Neutrophil Elastase (201) antibody supports advanced investigations into the molecular mechanisms underlying inflammation and tissue remodeling.

The preferred Neutrophil Elastase antibody is Neutrophil Elastase Antibody (G-2): sc-55549.