Date published: 2026-4-25

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Neutrophil Elastase Substrates

Santa Cruz Biotechnology now offers a broad range of Neutrophil Elastase Substrates for use in various applications. Neutrophil elastase is a serine protease enzyme primarily found in neutrophils, where it plays a key role in the body's defense against infections by degrading bacteria and other pathogens. Beyond its antimicrobial functions, neutrophil elastase is also involved in the remodeling of extracellular matrix components, influencing processes such as inflammation, wound healing, and tissue repair. Neutrophil Elastase Substrates are essential tools in scientific research, enabling the precise study of this enzyme's activity under various conditions. By using these substrates, researchers can investigate how neutrophil elastase contributes to both normal physiological processes and pathological conditions, such as chronic inflammatory diseases where excessive enzyme activity can lead to tissue damage and disease progression. These substrates are widely utilized in biochemical assays designed to measure enzyme kinetics, specificity, and inhibition, providing critical insights into the regulation of neutrophil elastase activity. Additionally, they are valuable in the development of potential therapeutic strategies aimed at modulating elastase activity to mitigate its harmful effects in conditions like chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The availability of Neutrophil Elastase Substrates has significantly advanced research in immunology, cell biology, and biochemistry, offering a deeper understanding of the complex roles this enzyme plays in health and disease. View detailed information on our available Neutrophil Elastase Substrates by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MeOSuc-AAPV-AMC

72252-90-5sc-201163
5 mg
$185.00
19
(2)

MeOSuc-AAPV-AMC is a selective substrate for neutrophil elastase, showcasing unique interactions that enhance its reactivity. The methoxysuccinyl group promotes enzyme affinity, while the AMC moiety serves as a fluorescent reporter, enabling real-time monitoring of enzymatic activity. Its design allows for efficient cleavage by elastase, resulting in a measurable fluorescence increase. This compound's kinetic profile reveals rapid substrate turnover, making it a valuable tool for studying elastase dynamics in various biological contexts.

MeOSuc-AAPV-pNA, Chromogenic Substrate

70967-90-7sc-201162
sc-201162A
sc-201162B
sc-201162C
sc-201162D
5 mg
10 mg
50 mg
250 mg
1 g
$104.00
$106.00
$219.00
$850.00
$2975.00
(1)

MeOSuc-AAPV-pNA is a chromogenic substrate specifically tailored for neutrophil elastase, featuring a p-nitroaniline (pNA) moiety that generates a colorimetric response upon enzymatic cleavage. The methoxysuccinyl group enhances binding affinity, facilitating efficient substrate recognition. Its unique structure allows for precise monitoring of elastase activity through absorbance changes, with a reaction kinetics profile that indicates a swift release of the chromophore, providing insights into enzyme behavior and activity modulation.