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MeOSuc-AAPV-AMC (CAS 72252-90-5) - chemical structure image
Molecular structure of MeOSuc-AAPV-AMC, CAS Number: 72252-90-5
MeOSuc-AAPV-AMC (CAS 72252-90-5) - chemical structure image
Molecular structure of MeOSuc-AAPV-AMC, CAS Number: 72252-90-5
Molecular structure of MeOSuc-AAPV-AMC, CAS Number: 72252-90-5

MeOSuc-AAPV-AMC (CAS 72252-90-5)

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Alternate Names:
Neutrophil elastase substrate (fluorogenic); N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin; Elastase Substrate V
Application:
MeOSuc-AAPV-AMC is a fluorogenic substrate used to assay elastase activity
CAS Number:
72252-90-5
Purity:
≥95%
Molecular Weight:
627.69
Molecular Formula:
C31H41N5O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

MeOSuc-AAPV-AMC is a fluorogenic substrate of neutrophil elastase. This compound can be used to assay elastase activity by spectrofluorometrically monitoring elastase-produced hydrolysis products. Assays of human leukocytes and porcine pancreatic elastase is described with use of MeOSuc-AAPV-AMC as a probe.


MeOSuc-AAPV-AMC (CAS 72252-90-5) References

  1. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.  |  Edwards, KM., et al. 1999. J Biol Chem. 274: 30468-73. PMID: 10521426
  2. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells.  |  Coles, B., et al. 2002. Circ Res. 91: 375-81. PMID: 12215485
  3. Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates.  |  Cloutier, SM., et al. 2004. Eur J Biochem. 271: 607-13. PMID: 14728688
  4. A serpin from the gut bacterium Bifidobacterium longum inhibits eukaryotic elastase-like serine proteases.  |  Ivanov, D., et al. 2006. J Biol Chem. 281: 17246-17252. PMID: 16627467
  5. The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families.  |  Brüning, M., et al. 2007. Biochem J. 401: 325-31. PMID: 16989645
  6. Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation.  |  Morrison, LS., et al. 2012. Cell Microbiol. 14: 1271-86. PMID: 22486816
  7. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.  |  von Nussbaum, F., et al. 2015. ChemMedChem. 10: 1163-73. PMID: 26083237
  8. Phenol-Soluble Modulin α Peptide Toxins from Aggressive Staphylococcus aureus Induce Rapid Formation of Neutrophil Extracellular Traps through a Reactive Oxygen Species-Independent Pathway.  |  Björnsdottir, H., et al. 2017. Front Immunol. 8: 257. PMID: 28337204
  9. Active NET formation in Libman-Sacks endocarditis without antiphospholipid antibodies: A dramatic onset of systemic lupus erythematosus.  |  Appelgren, D., et al. 2018. Autoimmunity. 51: 310-318. PMID: 30369267
  10. Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins.  |  Rasmuson, J., et al. 2019. FASEB J. 33: 10443-10452. PMID: 31216421
  11. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.  |  Zheng, Q., et al. 2019. Proc Natl Acad Sci U S A. 116: 18808-18814. PMID: 31484779
  12. Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.  |  Wilkinson, DJ., et al. 2022. FEBS J. 289: 121-139. PMID: 34270864
  13. Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity.  |  Donarska, B., et al. 2022. Int J Mol Sci. 23: PMID: 35886913
  14. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.  |  Castillo, MJ., et al. 1979. Anal Biochem. 99: 53-64. PMID: 394626

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MeOSuc-AAPV-AMC, 5 mg

sc-201163
5 mg
$153.00

Hello，Can this reagent detect elastase in pancreatic juice？

Asked by: wwmxd
Thank you for your question.It would be helpful if you could call us directly at (+86) 021-60936350 or email our Asia Service department at asia@scbio.cn for more interactive discussions on this and other related issues.
Answered by: Zhanglong
Date published: 2024-04-10

Hi, I was wondering which substrate is more specific for PR3 enzyme MeOSuc-AAPV-pNA or MeOSuc-AAPV-AMC?

Asked by: AAftab
Thank you for your question. MeOSuc-AAPV-pNA has been found to be a substrate for PR3, we do not have any literature supporting MeOSuc-AAPV-AMC being a highly sensitive substrate for PR3.
Answered by: Technical Support
Date published: 2017-04-05

Any recommendations for solubility in aqueous buffers?

Asked by: chemicalsmg
Thank you for your question. This chemical is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Solubility is approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-12
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Rated 5 out of 5 by from Easy to use for NE activity measurementThe substrate is easy to use for the measurement of neutrophil elastase activity in human neutrophils in a hydrolysis based fluorescence assay.
Date published: 2023-08-29
Rated 5 out of 5 by from Various publications cite the use of MeOSucVarious publications cite the use of MeOSuc-AAPV-AMC to assay elastase activity by spectrofluorometrically monitoring elastase-produced hydrolysis products. -SCBT Publication Review
Date published: 2015-06-09
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MeOSuc-AAPV-AMC is rated 5.0 out of 5 by 2.
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