neuroligin 3 Antibody (G-2): sc-271880

Neuroligin 3 Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects neuroligin 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neuroligin 3 is a crucial member of the neuroligin family, which is integral to the formation and remodeling of synapses in the central nervous system. Neuroligin 3 is primarily located in the plasma membrane of excitatory neurons, where neuroligin 3 plays a vital role in synaptic transmission by interacting with β-neurexins and other synaptic proteins. The binding of neuroligin 3 to β-neurexin 1β, which requires calcium ions, is essential for the stabilization of synaptic connections, thereby influencing neuronal communication and plasticity. Additionally, neuroligin 3 interacts with scaffolding proteins such as PSD-95, which is important for recruiting ion channels and neurotransmitter receptors to the synapse, ultimately affecting synaptic strength and efficacy. The ability of neuroligin 3 to mediate these interactions underscores neuroligin 3′s significance in synaptic function and potential implications in neurodevelopmental disorders.

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neuroligin 3 Antibody (G-2) References:

1. Isoform-specific cleavage of neuroligin-3 reduces synapse strength.  |  Bemben, MA., et al. 2019. Mol Psychiatry. 24: 145-160. PMID: 30242227
2. Neuroligin-3 and neuroligin-4X form nanoscopic clusters and regulate growth cone organization and size.  |  Gatford, NJF., et al. 2022. Hum Mol Genet. 31: 674-691. PMID: 34542148
3. Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction.  |  Uchigashima, M., et al. 2021. Front Mol Neurosci. 14: 749164. PMID: 34690695
4. Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo.  |  Muellerleile, J., et al. 2022. Mol Neurobiol. 59: 1098-1111. PMID: 34845591
5. Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses.  |  Han, Y., et al. 2022. Sci Adv. 8: eabo4173. PMID: 35704570
6. Neuroligin-3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure.  |  Brandner, DD., et al. 2023. Addict Biol. 28: e13247. PMID: 36577719
7. Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal-Glial Synapses and Reduced Expression in Nlgn3R451C Mice.  |  Herath, M., et al. 2023. Biomolecules. 13: PMID: 37509099
8. Neuroligin-3 activates Akt-dependent Nrf2 cascade to protect osteoblasts from oxidative stress.  |  Fan, JB., et al. 2023. Free Radic Biol Med. 208: 807-819. PMID: 37774803
9. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses.  |  Altas, B., et al. 2024. Biol Psychiatry. 96: 815-828. PMID: 38154503
10. Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice.  |  Lin, S., et al. 2024. Mol Psychiatry. 29: 2308-2320. PMID: 38459194

The preferred neuroligin 3 antibody is neuroligin 3 Antibody (C-3): sc-137052.