neuroligin 3 Antibody (C-3): sc-137052

neuroligin 3 Antibody (C-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects neuroligin 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-neuroligin 3 antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuroligins are crucial plasma membrane proteins that play a significant role in synaptic function and plasticity within the central nervous system. Specifically, neuroligin 3 is predominantly expressed in excitatory synapses and is essential for the formation and maintenance of synaptic connections. Neuroligin 3 interacts with β-neurexins, which are also located at the synapse, facilitating the recruitment of scaffolding proteins such as PSD-95. This interaction is vital for organizing the postsynaptic density and ensuring proper synaptic signaling. Neuroligin 3′s ability to bind to PSD-95 not only helps in anchoring ion channels and neurotransmitter receptors but also plays a role in synaptic remodeling, which is critical for learning and memory processes. neuroligin 3 monoclonal antibody (C-3) in various formats makes for an invaluable tool for researchers studying synaptic biology and related neurological disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

neuroligin 3 Antibody (C-3) References:

1. Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations.  |  Tsigelny, I., et al. 2000. Protein Sci. 9: 180-5. PMID: 10739260
2. The structure and expression of the human neuroligin-3 gene.  |  Philibert, RA., et al. 2000. Gene. 246: 303-10. PMID: 10767552
3. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.  |  Scheiffele, P., et al. 2000. Cell. 101: 657-69. PMID: 10892652
4. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.  |  Venkatesh, HS., et al. 2015. Cell. 161: 803-16. PMID: 25913192
5. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.  |  Venkatesh, HS., et al. 2017. Nature. 549: 533-537. PMID: 28959975
6. Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number.  |  Qin, L., et al. 2025. Mol Psychiatry. 30: 84-96. PMID: 39003414
7. Autism-associated neuroligin 3 deficiency in medial septum causes social deficits and sleep loss in mice.  |  Sun, H., et al. 2024. J Clin Invest. 134: PMID: 39058792
8. Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.  |  Dang, R., et al. 2024. Nat Commun. 15: 8639. PMID: 39366972
9. Structures, alternative splicing, and neurexin binding of multiple neuroligins.  |  Ichtchenko, K., et al. 1996. J Biol Chem. 271: 2676-82. PMID: 8576240
10. Binding of neuroligins to PSD-95.  |  Irie, M., et al. 1997. Science. 277: 1511-5. PMID: 9278515
11. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules.  |  Nguyen, T. and Südhof, TC. 1997. J Biol Chem. 272: 26032-9. PMID: 9325340
12. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.  |  Song, JY., et al. 1999. Proc Natl Acad Sci U S A. 96: 1100-5. PMID: 9927700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-neuroligin 3 Antibody (C-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-neuroligin 3 Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

neuroligin 3 Antibody (C-3) Specifications

Alternate Product Name: neuroligin 3

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 649-703

Epitope Target: neuroligin 3

Epitope Species: human

Product Reactivity/Detection: neuroligin 3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for neuroligin 3 Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin