Neurogranin Antibody (H-6): sc-514922

Neurogranin Antibody (H-6) is a mouse monoclonal IgG2a antibody that detects neurogranin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neurogranin is a crucial postsynaptic protein predominantly found in the brain, particularly enriched in regions such as the cortex, striatum, hippocampus, thalamus, hypothalamus, and olfactory bulb nuclei. Neurogranin′s primary function involves binding calmodulin at low calcium levels, which plays a significant role in regulating calmodulin-dependent nitric oxide synthase activity, thereby influencing synaptic plasticity and cognitive functions. Notably, neurogranin undergoes post-translational modifications, including phosphorylation by protein kinase C, which can alter calmodulin binding ability. This phosphorylation occurs at a specific domain adjacent to the calmodulin-binding region, highlighting the intricate regulatory mechanisms that govern neurogranin′s function in neuronal signaling. Anti-neurogranin antibody (H-6) serves as an essential tool for researchers investigating the dynamics of synaptic transmission and the molecular underpinnings of neurodegenerative diseases.

The preferred Neurogranin antibody is Neurogranin Antibody (C-7): sc-515092.