neuroglobin Antibody (G-11): sc-133086

neuroglobin Antibody (G-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects neuroglobin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-neuroglobin antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuroglobin (Ngb) is a hexacoordinate hemoglobin primarily expressed in the vertebrate brain, where Ngb plays a crucial role in enhancing oxygen supply to neural components. Ngb exhibits a high affinity for oxygen, which is vital for maintaining neuronal function, particularly under conditions of hypoxia or ischemia. Ngb′s ability to increase in response to neuronal hypoxia suggests a protective role in promoting cell survival during oxygen deprivation. The human neuroglobin gene is located on chromosome 14q24 and encodes a 151 amino acid protein, making Ngb an important factor in the brain′s adaptive responses to stress. Using neuroglobin monoclonal antibody (G-11), researchers can explore the intricate mechanisms of neuroglobin in neuronal health and disease, providing insights into potential therapeutic targets for neuroprotection.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

neuroglobin Antibody (G-11) References:

1. A vertebrate globin expressed in the brain.  |  Burmester, T., et al. 2000. Nature. 407: 520-3. PMID: 11029004
2. Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen.  |  Trent, JT., et al. 2001. J Biol Chem. 276: 30106-10. PMID: 11429401
3. The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket.  |  Couture, M., et al. 2001. J Biol Chem. 276: 36377-82. PMID: 11473111
4. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family.  |  Dewilde, S., et al. 2001. J Biol Chem. 276: 38949-55. PMID: 11473128
5. [Coding region cDNA sequence cloning of rat neuroglobin gene, its polymorphism feature and tissue expression profile analysis].  |  Zhang, CG., et al. 2001. Yi Chuan Xue Bao. 28: 997-1001. PMID: 11725647
6. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury.  |  Sun, Y., et al. 2001. Proc Natl Acad Sci U S A. 98: 15306-11. PMID: 11742077
7. Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin.  |  Zhang, C., et al. 2002. Biochem Biophys Res Commun. 290: 1411-9. PMID: 11820779
8. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues.  |  Burmester, T., et al. 2002. Mol Biol Evol. 19: 416-21. PMID: 11919282
9. The potential of mitochondrial modulation by neuroglobin in treatment of neurological disorders.  |  Gorabi, AM., et al. 2021. Free Radic Biol Med. 162: 471-477. PMID: 33166649
10. Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer.  |  Xiang, Q., et al. 2023. Clin Epigenetics. 15: 57. PMID: 37005662
11. The Role of Neuroglobin in the Sleep-Wake Cycle.  |  García-García, F., et al. 2023. Sleep Sci. 16: e362-e367. PMID: 38196764
12. Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior.  |  Cwerman-Thibault, H., et al. 2024. Mol Ther. 32: 2150-2175. PMID: 38796706

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-neuroglobin Antibody (G-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-neuroglobin Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

neuroglobin Antibody (G-11) Specifications

Alternate Product Name: neuroglobin

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-151

Epitope Target: neuroglobin

Epitope Species: human

Product Reactivity/Detection: neuroglobin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for neuroglobin Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin