Neurofibromin Antibody (McNFn27b): sc-20016
- Neurofibromin Antibody (McNFn27b) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 27-41 corresponding to an N-terminal peptide of Neurofibromin of human origin
- recommended for detection of Neurofibromin of mouse, rat and human origin by WB, IF and IHC(P)
- See Neurofibromin (H-12): sc-376886 for Neurofibromin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Neurofibromin Antibody (McNFn27b) for WB and IHC(P) applications. These reagents are now offered in bundles with Neurofibromin Antibody (McNFn27b) (see ordering information below).
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Neurofibromin Antibody (McNFn27b) is a mouse monoclonal IgG1 antibody that detects Neurofibromin in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Neurofibromin, also known as NF1-GAP-related protein, is a crucial 2,818 amino acid protein encoded by the NF1 gene located on chromosome 17, and plays a significant role in regulating cell growth and differentiation by acting as a GTPase-activating protein for Ras proteins. Anti-Neurofibromin antibody (McNFn27b) helps researchers study interactions between Neurofibromin and Ras, which are particularly important for controlling cellular signaling pathways that, when dysregulated, can lead to tumorigenesis and other disorders, including neurofibromatosis type 1. Neurofibromin is expressed consistently across various tissues, including the brain, lung, liver, kidney, spleen, muscle, and colon, highlighting its fundamental role in maintaining normal cellular functions. Neurofibromin′s ability to modulate Ras activity underscores its potential as a therapeutic target in conditions associated with Ras signaling dysregulation, making Neurofibromin (McNFn27b) monoclonal antibody an invaluable tool for studying these pathways and their implications in disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neurofibromin Antibody (McNFn27b) | sc-20016 | 200 µg/ml | $322.00 | |||
Neurofibromin Antibody (McNFn27b): m-IgG Fc BP-HRP Bundle | sc-536639 | 200 µg Ab; 10 µg BP | $361.00 | |||
Neurofibromin Antibody (McNFn27b): m-IgGκ BP-HRP Bundle | sc-533796 | 200 µg Ab; 40 µg BP | $361.00 | |||
Neurofibromin Antibody (McNFn27b): m-IgG1 BP-HRP Bundle | sc-544724 | 200 µg Ab; 20 µg BP | $361.00 |