Neurofibromin Antibody (McNFn27a): sc-20017

Neurofibromin Antibody (McNFn27a) is a mouse monoclonal IgG1 antibody that detects Neurofibromin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Neurofibromin, also known as NF1-GAP-related protein, is a crucial 2,818 amino acid protein encoded by the NF1 gene located on chromosome 17, which is associated with neurofibromatosis type 1, one of the most prevalent autosomal dominant disorders. Anti-Neurofibromin antibody (McNFn27a) recognizes a protein that plays a significant role in regulating cell growth and differentiation by acting as a GTPase-activating protein (GAP) for Ras proteins, which are pivotal in cell signaling pathways that control various cellular functions, including proliferation and survival. The interaction between Neurofibromin and Ras proteins is vital, as Neurofibromin helps maintain normal cellular functions and prevents uncontrolled cell growth, which can lead to tumorigenesis. Neurofibromin is expressed consistently across a wide array of tissues, including the brain, lung, liver, kidney, spleen, muscle, and colon, highlighting its importance in various physiological processes. Neurofibromin′s ability to modulate Ras activity underscores its potential as a therapeutic target in conditions associated with Ras dysregulation, making Neurofibromin (McNFn27a) monoclonal antibody an essential tool for researchers studying neurofibromatosis and related signaling pathways.

The preferred Neurofibromin antibody is Neurofibromin Antibody (H-12): sc-376886.