Neuro D2 Antibody (G-10): sc-365896

Neuro D2 Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Neuro D2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neuro D2 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuro D2, also known as neurogenic differentiation 2, NDRF, or bHLHa1, is a crucial 382 amino acid nuclear protein that plays a significant role in neurogenesis by inducing the differentiation of neural progenitor cells into neurons. This protein contains a basic helix-loop-helix (bHLH) domain, which is essential for its function as a transcription factor that regulates gene expression during neuronal development. Neuro D2′s ability to influence cell fate determination is vital for proper nervous system development and function, as this protein helps establish the identity of neuronal cells and their subsequent differentiation. Furthermore, Neuro D2 interacts with other transcription factors within the myogenic determination family, which includes both class A and class B bHLH proteins, to coordinate the complex processes of cell lineage specification and differentiation. The precise regulation of Neuro D2 and its interactions with other proteins are critical for maintaining the balance between proliferation and differentiation in neural tissues, making Neuro D2 an important target for research in neurodevelopmental disorders and regenerative medicine.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Neuro D2 Antibody (G-10) References:

1. Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2.  |  Shibata, H., et al. 1999. Brain Res Mol Brain Res. 74: 126-34. PMID: 10640683
2. NeuroD homologue expression during cortical development in the human brain.  |  Franklin, A., et al. 2001. J Child Neurol. 16: 849-53. PMID: 11732772
3. The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.  |  Westerman, BA., et al. 2002. Mech Dev. 113: 85-90. PMID: 11900979
4. NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells.  |  Westerman, BA., et al. 2004. Biochim Biophys Acta. 1676: 96-103. PMID: 14732494
5. A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior.  |  Zill, P., et al. 2006. Mol Psychiatry. 11: 525-7. PMID: 16607387
6. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.  |  McCormick, MB., et al. 1996. Mol Cell Biol. 16: 5792-800. PMID: 8816493
7. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively.  |  Tamimi, RM., et al. 1997. Genomics. 40: 355-7. PMID: 9119405
8. Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein.  |  Kume, H., et al. 1998. Brain Res Mol Brain Res. 60: 107-14. PMID: 9748526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neuro D2 Antibody (G-10) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Neuro D2 Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neuro D2 Antibody (G-10) Specifications

Alternate Product Name: Neuro D2 (neuronal differentiation) 2

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 308-368

Epitope Target: Neuro D2

Epitope Species: human

Product Reactivity/Detection: Neuro D2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Neuro D2 Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent