ErbB2/HER2 Antibody (A-2): sc-393712

Neu Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Neu in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-Neu antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neu, also known as ErbB-2 or HER2, is a member of the epidermal growth factor receptor (EGFR) family, which consists of receptor tyrosine kinases that are often overexpressed in numerous carcinomas. Upon ligand binding, Neu can form homodimers or heterodimers with other EGFR family members, such as ErbB-3. This heterodimerization is crucial as it leads to the recruitment of heregulin, which activates phosphoinositide 3-kinase, a key player in various cellular processes including cell growth, survival, and motility. The aberrant expression of Neu, which occurs in 20-30% of breast cancers, is associated with poor prognosis, making Neu a vital biomarker for disease progression and a promising target for therapeutic interventions. Neu monoclonal antibody (A-2) enables researchers to gain insights into Neu′s role in cancer biology and explore potential treatment strategies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ErbB2/HER2 Antibody (A-2) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-ErbB2/HER2 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ErbB2/HER2 Antibody (A-2) Specifications

Alternate Product Name: HER2

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1180-1197

Epitope Target: Neu

Epitope Species: human

Product Reactivity/Detection: Neu

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for ErbB2/HER2 Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred antibody is Antibody (): sc-8.