netrin G1 Antibody (H-4): sc-393665

netrin G1 Antibody (H-4) is a mouse monoclonal IgG1 antibody that detects netrin G1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Netrin G1 is a crucial axon guidance molecule that plays a significant role in synaptic formation and maintenance, particularly in the central nervous system. Proper functioning of netrin G1 is essential for neuronal connectivity and communication, which are vital for cognitive processes and overall brain health. Notably, netrin G1 is predominantly expressed in the thalamus, where netrin G1 influences NMDA receptor activity, a key player in synaptic plasticity and memory formation. Dysregulation of netrin G1 has been implicated in various neurodevelopmental disorders, including Rett syndrome, atypical autism, epilepsy, and mental retardation, highlighting netrin G1′s importance in both normal brain function and disease. Unique structural features of netrin G1, including glycosyl phosphatidylinositol membrane anchor and multiple isoforms, further underscore netrin G1′s complexity and functional diversity in the brain. Anti-netrin G1 antibody (H-4) is an invaluable tool for researchers investigating the intricate roles of netrin G1 in neurobiology and potential links to psychiatric conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

netrin G1 Antibody (H-4) References:

1. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.  |  Nakashiba, T., et al. 2000. J Neurosci. 20: 6540-50. PMID: 10964959
2. Complementary expression and neurite outgrowth activity of netrin-G subfamily members.  |  Nakashiba, T., et al. 2002. Mech Dev. 111: 47-60. PMID: 11804778
3. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.  |  Lin, JC., et al. 2003. Nat Neurosci. 6: 1270-6. PMID: 14595443
4. Human netrin-G1 isoforms show evidence of differential expression.  |  Meerabux, JM., et al. 2005. Genomics. 86: 112-6. PMID: 15901489
5. Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.  |  Nishimura-Akiyoshi, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 14801-6. PMID: 17785411
6. The NGL family of leucine-rich repeat-containing synaptic adhesion molecules.  |  Woo, J., et al. 2009. Mol Cell Neurosci. 42: 1-10. PMID: 19467332
7. The netrin G1 gene rs628117 polymorphism is associated with ischemic stroke.  |  Stepanyan, A., et al. 2013. Neurosci Lett. 549: 74-7. PMID: 23769687
8. Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.  |  Zhang, Q., et al. 2016. Mol Brain. 9: 6. PMID: 26746425
9. Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human cocaine dependence.  |  Kelaï, S., et al. 2018. Addict Biol. 23: 448-460. PMID: 28074533
10. 2-Deoxy-D-Glucose Exhibits Anti-seizure Effects by Mediating the Netrin-G1-KATP Signaling Pathway in Epilepsy.  |  Long, Y., et al. 2019. Neurochem Res. 44: 994-1004. PMID: 30805800

The preferred netrin G1 antibody is netrin G1 Antibody (D-2): sc-271774.