Nek7 Antibody (A-12): sc-398439

Nek7 Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects Nek7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nek7 plays a crucial role in the regulation of mitosis, particularly during the G2 to M phase transition, where Nek7 expression peaks, similar to its closest relative, Nek2. Nek7 is primarily localized in the cytoplasm and is highly expressed in various tissues, including lung, testis, muscle, spleen, heart, liver, leukocytes, and brain, while showing lower expression levels in the ovary, prostate, and kidney, and absent in the small intestine. Nek7′s cellular localization is important for coordinating cell division, which is essential for maintaining proper cellular function and preventing diseases such as cancer. Additionally, aberrations in Nek7 expression have been linked to various pathologies, making Nek7 a significant target for research in cell cycle regulation and related disorders. Anti-Nek7 antibody (A-12) is an invaluable tool for researchers aiming to explore the intricate mechanisms of mitosis and its implications in health and disease.

The preferred Nek7 antibody is Nek7 Antibody (B-5): sc-393539.