Nectin 2 Antibody (6A606): sc-71660

Nectin 2 Antibody (6A606) is a rat monoclonal IgG2a antibody that detects Nectin 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Nectin 2 is a crucial member of the nectin family, which plays a significant role in cell adhesion and communication, particularly in viral entry mechanisms. Nectin 2 is predominantly expressed in various human cell types, including neuronal cell lines, fibroblasts, keratinocytes, and activated T lymphocytes, highlighting its importance in both neural and immune responses. Nectin 2 exists in two splicing variants, Nectin 2α and Nectin 2δ, which differ in their cytoplasmic and transmembrane regions while sharing identical extracellular domains. The C-terminal conserved motif present in both variants is essential for interaction with the PDZ domain of afadin, linking Nectin 2 to the actin cytoskeleton and facilitating cellular adhesion. Nectin 2 mediates the entry of specific herpes simplex virus strains, underscoring its role in viral pathogenesis and potential implications in therapeutic strategies. Furthermore, Nectin 2δ undergoes tyrosine phosphorylation in response to cell-cell adhesion, a post-translational modification that may influence functional dynamics and interactions within the cellular environment. Anti-Nectin 2 antibody (6A606) serves as an invaluable tool for researchers investigating cell adhesion processes and viral entry mechanisms.

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Nectin 2 Antibody (6A606) References:

1. Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals.  |  Struyf, F., et al. 2002. J Infect Dis. 185: 36-44. PMID: 11756979
2. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.  |  Bottino, C., et al. 2003. J Exp Med. 198: 557-67. PMID: 12913096
3. Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1.  |  Yoon, M., et al. 2003. J Virol. 77: 9221-31. PMID: 12915538
4. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).  |  Tahara-Hanaoka, S., et al. 2004. Int Immunol. 16: 533-8. PMID: 15039383
5. Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.  |  Satomi-Kobayashi, S., et al. 2009. Hypertension. 54: 825-31. PMID: 19667252
6. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.  |  Samanta, D., et al. 2012. Proc Natl Acad Sci U S A. 109: 14836-40. PMID: 22927415
7. Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells.  |  Fujimoto, Y., et al. 2016. Acta Virol. 60: 41-8. PMID: 26982466
8. Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin.  |  Duraivelan, K., et al. 2018. Proteins. 86: 1157-1164. PMID: 30183103
9. The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.  |  Rajendrakumar, AL., et al. 2024. BMC Neurol. 24: 78. PMID: 38408961
10. The association between rs6859 in NECTIN2 gene and Alzheimer's disease is partly mediated by pTau.  |  Rajendrakumar, AL., et al. 2024. Front Aging Neurosci. 16: 1388363. PMID: 39165837

The preferred Nectin 2 antibody is Nectin 2 Antibody (E-1): sc-271236.